ArticleMagnetic resonance in medicine2017
Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Multi-echo acquisition and thermal denoising advances precision functional imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.Developmental cognitive neuroscience · 2024Article
- Large Numbers for Small Children-Up to What Age Do Infants Benefit from a Longer Echo Time in Cerebral T2 MRI Sequences?Children (Basel, Switzerland) · 2024Article
- Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study.Prenatal diagnosis · 2024Article
- Functional neuroimaging of responses to multiple sensory stimulations in newborns with perinatal asphyxia.Translational pediatrics · 2023Article
- Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure.Communications biology · 2023Article
- Network-specific selectivity of functional connections in the neonatal brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T.Tomography (Ann Arbor, Mich.) · 2021Article
- Functional and diffusion MRI reveal the neurophysiological basis of neonates' noxious-stimulus evoked brain activity.Nature communications · 2021Article
- MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances.Journal of magnetic resonance imaging : JMRI · 2021Review
- Nociception and the neonatal brain.Seminars in fetal & neonatal medicine · 2019Review
- Neural correlates of gentle skin stroking in early infancy.Developmental cognitive neuroscience · 2019Article
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9 authors at 1 institution in 1 country.
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Abstract
purposeBlood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin-spin relaxation time constant ( T2*) that describes the decay of transverse magnetization. Use of the optimal TE during fMRI experiments allows maximal sensitivity to BOLD to be achieved. Reports that T2* values are longer in infants (due to higher water concentrations and lower lipid content) have led to the use of longer TEs during infant fMRI experiments; however, the optimal TE has not been established.
methodsIn this study, acute experimental mildly noxious stimuli were applied to the heel in 12 term infants (mean gestational age = 40 weeks, mean postnatal age = 3 days); and the percentage change in BOLD activity was calculated across a range of TEs, from 30 to 70 ms, at 3 Tesla. In addition, T2* maps of the whole brain were collected in seven infants.
resultsThe maximal change in BOLD occurred at a TE of 52 ms, and the average T2* across the whole brain was 99 ms.
conclusionA TE of approximately 50 ms is recommended for use in 3T fMRI investigations in term infants. Magn Reson Med 78:625-631, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
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