ArticleAmerican journal of respiratory and critical care medicine2017
Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00114881 (Urban Environment and Childhood Asthma), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urban Environment and Childhood Asthma (URECA)
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Prenatal depression and psychotropics in offspring asthma and atopic dermatitis.Journal of the Chinese Medical Association : JCMA · 2026Article
- Childhood Environmental Exposures and Adult Disease.Pediatric pulmonology · 2026Review
- Longitudinally investigating patterns of maternal psychological distress in a South African birth cohort.BMC public health · 2025Article
- Caregiver-Perceived Determinants of Asthma Morbidity in Early Childhood: A Qualitative Study.Hospital pediatrics · 2025Article
- Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Postpartum Maternal Anxiety Affects the Development of Food Allergy Through Dietary and Gut Microbial Diversity During Early Infancy.Allergy, asthma & immunology research · 2024Article
- Social determinants of health influence preschool and caregiver experiences during symptoms and exacerbations of wheezing.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Poorer Caregiver Mental and Social Health Is Associated With Worse Respiratory Outcomes in Preschool Children With Recurrent Wheezing.The journal of allergy and clinical immunology. In practice · 2023Article
- Early childhood wheezing phenotypes and determinants in a South African birth cohort: longitudinal analysis of the Drakenstein Child Health Study.The Lancet. Child & adolescent health · 2023Article
- Brain-Airway Interactions in Asthma.Advances in experimental medicine and biology · 2023Article
- Cytokine expression in rhinovirus- vs. respiratory syncytial virus-induced first wheezing episode and its relation to clinical course.Frontiers in immunology · 2022Article
- Adenotonsillectomy, bronchoscopy and bronchoalveolar lavage in the management of preschool children with severe asthma: pilot study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Maternal stress and depression are associated with respiratory phenotypes in urban children.The Journal of allergy and clinical immunology · 2021Article
- A worldwide charter for all children with asthma.Pediatric pulmonology · 2020Article
- Association between maternal psychological adversity and lung function in South African infants: A birth cohort study.Pediatric pulmonology · 2020Article
- Prenatal Maternal Depression and Neonatal Immune Responses.Psychosomatic medicine · 2019Article
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- Sex-specific association between prenatal life stress exposure and infant pro-inflammatory cytokine levels during acute respiratory infection.Brain, behavior, and immunity · 2019Article
- Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.American journal of respiratory and critical care medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
rationaleMaternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development.
objectivesTo test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.
methodsURECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years. MEASUREMENTS AND MAIN
resultsOverall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P < 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P ≤ 0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P ≤ 0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses.
conclusionsIn urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.