ArticleKidney international2016
Preemptive kidney transplantation is associated with survival benefits among pediatric patients with end-stage renal disease.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- The psychosocial factors influencing paediatric kidney transplantation access, their outcomes and the patient and family's perceived quality of life: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Comparison of Kidney Transplantation Outcomes Between Patients with and Without Pre-transplantation Bariatric Surgery: a Systematic Review.Obesity surgery · 2022Pooled it
- Association Between Pretransplant Dialysis Modality and Kidney Transplant Outcomes: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Is Preemptive Kidney Transplantation Associated With Improved Outcomes when Compared to Non-preemptive Kidney Transplantation in Children? A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Equitable access to pediatric kidney transplantation: bridging the gap-the view from low- to lower-middle-income countries.Pediatric nephrology (Berlin, Germany) · 2026Review
- Association between estimated time with low glomerular filtration rate and access to transplant among youth with advanced chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- Pediatric Kidney Transplantation: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Holding On or Letting Go: Immunosuppression After Pediatric Kidney Allograft Failure.Pediatric transplantation · 2026Review
- Green nephrology: environmentally sustainable kidney care in pediatrics.Pediatric nephrology (Berlin, Germany) · 2026Review
- Effects of dialysis therapies on circulating levels of endothelial markers after kidney transplant in children: focus on positive aspect of peritoneal dialysis.Clinical and experimental nephrology · 2026Article
- Donor Risk Factors Affecting Graft Survival in Pediatric Kidney Transplants: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2026Article
- Management of Surgical Complications in Pediatric Kidney Transplantation.Journal of clinical medicine · 2026Review
- A novel preoperative simulation approach for pediatric kidney transplantation to support donor-recipient size matching using dialysis fluid-enhanced CT imaging and 3D printing.Frontiers in transplantation · 2026Article
- Consent to Receive Offers for Kidneys From Donors With Hepatitis C Among Pediatric Kidney Transplant Candidates in the United States.Pediatric transplantation · 2025Article
- [Kidney transplantation in low-age, low-weight children: A report of two cases].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Kidney Transplantation in Children Weighing Less than 15 kg: A 35-Year Single-Center Experience.Journal of clinical medicine · 2025Article
- Pediatric Nephrology Workforce and Access of Children with Kidney Failure to Transplantation in the United States.Journal of the American Society of Nephrology : JASN · 2025Article
- Trends in Timing of Preemptive Kidney Transplantation and Association with Allograft and Survival Outcomes in Children.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Neighborhood Disadvantage and Inequities in Access to Preemptive and Living Kidney Transplantation.Kidney360 · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Kidney transplantation is the preferred treatment for pediatric end-stage renal disease (ESRD). Preemptive transplantation avoids the increased morbidity and mortality of dialysis. Yet, previous studies have not demonstrated significant graft or patient survival benefits for children undergoing transplantation preemptively versus nonpreemptively. These previous studies were limited by small samples sizes and low rates of adverse events. Here we compared graft failure and mortality rates using Kaplan-Meier methods and Cox regression among a large national cohort of children with ESRD undergoing preemptive versus nonpreemptive kidney transplantation between 2000 and 2012. Among 7527 pediatric kidney transplant recipients in the United States Renal Data System, 1668 underwent preemptive transplantation. Over a median 4.8 years follow-up, 1314 experienced graft failure, and over a median 5.2 years of follow-up, 334 died. Dialysis exposure versus preemptive transplantation conferred a higher risk of graft failure (hazard ratio 1.32; 95% confidence interval: 1.10-1.56) and a higher risk of death (hazard ratio 1.69; 95% confidence interval: 1.22-2.33) in multivariable analysis. Compared with children undergoing preemptive transplantation, children on dialysis for >1 year had a 52% higher risk of graft failure and those on dialysis >18 months had an 89% higher risk of death, regardless of donor source. Thus, preemptive transplantation is associated with substantial benefits in allograft and patient survival among children with ESRD, particularly when compared with children who receive dialysis for >1 year. These findings support policies to promote early access to transplantation and avoidance of dialysis for children with ESRD whenever feasible.
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Registered trials
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