ArticleMolecular pharmaceutics2016
Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot.
Article in Molecular pharmaceutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Pulsatile Release of Human Gonadotropin Releasing Hormone Using a Photoactivated Depot Containing an Unusual Light Cleaved Functionality.Molecular pharmaceutics · 2026Article
- The Photoactivated Depot (PAD): Light Triggered Control of Therapeutic Protein Solubility and Release.Accounts of chemical research · 2025Article
- A Green Light-Activated Insulin Depot with Ultrafast In Vivo Efficiency in the Subcutaneous Space.ACS biomaterials science & engineering · 2024Article
- Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management.Molecules (Basel, Switzerland) · 2024Article
- In vivo variable and multi-day response from an insulin-releasing photoactivated depot.Bioorganic & medicinal chemistry letters · 2023Article
- Glucose-activatable insulin delivery with charge-conversional polyelectrolyte multilayers for diabetes care.Frontiers in bioengineering and biotechnology · 2022Article
- The Issue of Tissue: Approaches and Challenges to the Light Control of Drug Activity: A Mini-Review.ChemPhotoChem · 2021Article
- A Light Activated Glucagon Trimer with Resistance to Fibrillation.ACS biomaterials science & engineering · 2021Article
- Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency.Biomacromolecules · 2020Article
- Replacing Pumps with Light Controlled Insulin Delivery.Current diabetes reports · 2019Review
- Visible-Light-Activated High-Density Materials for Controlled in Vivo Insulin Release.Molecular pharmaceutics · 2019Article
- Engineering the vasculature for islet transplantation.Acta biomaterialia · 2019Review
- Hydrophobic Tags for Highly Efficient Light-Activated Protein Release.Molecular pharmaceutics · 2019Article
- Chemical modification of proteins with photocleavable groups.Methods in enzymology · 2019Article
- Optochemical Control of Biological Processes in Cells and Animals.Angewandte Chemie (International ed. in English) · 2018Review
- Ruthenium-Crosslinked Hydrogels with Rapid, Visible-Light Degradation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Light Control of Protein Solubility Through Isoelectric Point Modulation.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this work we demonstrate that blood glucose can be controlled remotely through light stimulated release of insulin from an injected cutaneous depot. Human insulin was tethered to an insoluble but injectable polymer via a linker, which was based on the light cleavable di-methoxy nitrophenyl ethyl (DMNPE) group. This material was injected into the skin of streptozotocin-treated diabetic rats. We observed insulin being released into the bloodstream after a 2 min trans-cutaneous irradiation of this site by a compact LED light source. Control animals treated with the same material, but in which light was blocked from the site, showed no release of insulin into the bloodstream. We also demonstrate that additional pulses of light from the light source result in additional pulses of insulin being absorbed into circulation. A significant reduction in blood glucose was then observed. Together, these results demonstrate the feasibility of using light to allow for the continuously variable control of insulin release. This in turn has the potential to allow for the tight control of blood glucose without the invasiveness of insulin pumps and cannulas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.