ArticleCell reports2016
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes.bioRxiv : the preprint server for biology · 2026Article
- H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.Nature communications · 2026Article
- Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance.Nature plants · 2025Article
- Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism inScience advances · 2025Article
- Article
- TheNeural regeneration research · 2024Article
- Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.Frontiers in cell and developmental biology · 2024Article
- Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix.Frontiers in molecular biosciences · 2022Article
- Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.Current opinion in structural biology · 2021Review
- MORC protein family-related signature within human disease and cancer.Cell death & disease · 2021Review
- The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.Epigenetics & chromatin · 2021Article
- Searching for methyllysine-binding aromatic cages.The Biochemical journal · 2021Article
- MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells.Scientific reports · 2021Article
- Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.Nature communications · 2021Article
- MORC2 Interactome: Its Involvement in Metabolism and Cancer.Biophysical reviews · 2021Review
- Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation.Nature communications · 2021Article
- Molecular mechanism of the MORC4 ATPase activation.Nature communications · 2020Article
- A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment.Nature microbiology · 2020Article
- MORC3 Forms Nuclear Condensates through Phase Separation.iScience · 2019Article
- MORC3 Is a Target of the Influenza A Viral Protein NS1.Structure (London, England : 1993) · 2019Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
MORC3 is linked to inflammatory myopathies and cancer; however, the precise role of MORC3 in normal cell physiology and disease remains poorly understood. Here, we present detailed genetic, biochemical, and structural analyses of MORC3. We demonstrate that MORC3 is significantly upregulated in Down syndrome and that genetic abnormalities in MORC3 are associated with cancer. The CW domain of MORC3 binds to the methylated histone H3K4 tail, and this interaction is essential for recruitment of MORC3 to chromatin and accumulation in nuclear bodies. We show that MORC3 possesses intrinsic ATPase activity that requires DNA, but it is negatively regulated by the CW domain, which interacts with the ATPase domain. Natively linked CW impedes binding of the ATPase domain to DNA, resulting in a decrease in the DNA-stimulated enzymatic activity. Collectively, our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease.
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