Evidence map›Paper›PMID 27653600›Full record

ReviewImmunity2016

Germinal Center B Cell Dynamics.

Luka Mesin, Jonatan Ersching, Gabriel D Victora

Abstract readReview
In one paragraph

Review in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 632 papers.

0numbers the graph read from it
0cells of the map it votes in
632citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

632 citing papers in PubMed.

  1. Trial
  2. Article
  3. Non-Proliferative Immune Restoration byJournal of microbiology and biotechnology · 2026
    Article
  4. Review
  5. Review
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  7. Article
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  11. Article
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  13. Article
  14. Review
  15. Article
  16. Article
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  18. Article
  19. Article
  20. Article

572 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luka MesinWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Jonatan ErschingWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Gabriel D VictoraWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: victora@rockefeller.edu.

Funding

IN VIVO APPROACHES TO DISSECTING B CELL-T CELL COOPERATION IN GERMINAL CENTERSDP5OD012146 · OD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI VICTORA, GABRIEL D · 2012 to 2016
$2.4M
NIH HHS DP5 OD012146
6 · The paper itself

Abstract

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

Indexed as

AnimalsAntibodiesAntibody AffinityB-LymphocytesGerminal CenterHumansImmunityAntibodies

Identifiers

PMID27653600
PMCPMC5123673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.