Evidence map›Paper›PMID 27653553›Full record

ArticleScientific reports2016

Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model.

Sheng Fong, Emelyne Teo, Li Fang Ng, Ce-Belle Chen, Lakshmi Narayanan Lakshmanan, Sau Yee Tsoi, Philip Keith Moore, Takao Inoue, Barry Halliwell, Jan Gruber

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Frontiers in aging neuroscience · 2026
    Review
  5. Systematic optimization ofBiochemistry and biophysics reports · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Olfactory dysfunction as an early pathogenic indicator inFrontiers in aging neuroscience · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Biomolecules · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sheng FongInternal Medicine Residency Programme, SingHealth Group, Singapore.
Emelyne TeoNUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
Li Fang NgScience Division, Yale-NUS College, Singapore.
Ce-Belle ChenDepartment of Biochemistry, National University of Singapore, Singapore.
Lakshmi Narayanan LakshmananInstitute of Chemical and Bioengineering, ETH Zurich, Switzerland.
Sau Yee TsoiScience Division, Yale-NUS College, Singapore.
Philip Keith MooreNUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
Takao InoueDepartment of Biochemistry, National University of Singapore, Singapore.
Barry HalliwellDepartment of Biochemistry, National University of Singapore, Singapore.
Jan GruberScience Division, Yale-NUS College, Singapore.
National University of Singapore · SGYale-NUS College · SGETH Zurich · CHSingHealth · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer Disease (AD) is a progressive neurological disorder characterized by the deposition of amyloid beta (Aβ), predominantly the Aβ

Identifiers

PMID27653553
PMCPMC5031964
OpenAlexW2522057030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.