ArticleNature communications2016
Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Shining Light into Adolescent HIV Neuroplasticity: A Study of the Prefrontal Cortex Using Functional Near Infrared Spectrometry.F1000Research · 2025Trial
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- Uncertainty and reward histories have distinct effects on decisions after wins and losses.Scientific reports · 2026Article
- Abstract rule learning promotes cognitive flexibility in complex environments across species.Nature communications · 2025Article
- Transformations in prefrontal ensemble activity underlying rapid threat avoidance learning.Current biology : CB · 2025Article
- Rhythmic modulation of dorsal hippocampus across distinct behavioral timescales during spatial set-shifting.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal cortex synchronization with the hippocampus and parietal cortex is strategy-dependent during spatial learning.Communications biology · 2025Article
- Broadscale dampening of uncertainty adjustment in the aging brain.Nature communications · 2024Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Characterization of neuronal oscillations in the prelimbic cortex, nucleus accumbens and CA1 hippocampus during object retrieval task in rats predisposed to early life stress.Behavioral and brain functions : BBF · 2024Article
- Fiber photometry in neuroscience research: principles, applications, and future directions.Pharmacological reports : PR · 2024Review
- A Prefrontal→Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Impulsive Choices Emerge When the Anterior Cingulate Cortex Fails to Encode Deliberative Strategies.eNeuro · 2024Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Article
- Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Article
- A computational model of prefrontal and striatal interactions in perceptual category learning.Brain and cognition · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The ability to change behavioural strategies in the face of a changing world has been linked to the integrity of medial prefrontal cortex (mPFC) function in several species. While recording studies have found that mPFC representations reflect the strategy being used, lesion studies suggest that mPFC is necessary for changing strategy. Here we examine the relationship between representational changes in mPFC and behavioural strategy changes in the rat. We found that on tasks with a forced change in reward criterion, strategy-related representational transitions in mPFC occurred after animals learned that the reward contingency had changed, but before their behaviour changed. On tasks in which animals made their own strategic decisions, representational transitions in mPFC preceded changes in behaviour. These results suggest that mPFC does not merely reflect the action-selection policy of the animal, but rather that mPFC processes information related to a need for a change in strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.