Evidence map›Paper›PMID 27653233›Full record

ArticleJournal of biophotonics2016

Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling.

Rozhin Penjweini, Michele M Kim, Baochang Liu, Timothy C Zhu

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of biophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Photodynamic Therapy: Past, Current, and Future.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Physics in medicine and biology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Reactive oxygen species explicit dosimetry to predict tumor growth for BPD-mediated vascular photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2019
    Article
  12. Article
  13. Reactive Oxygen Species Explicit Dosimetry (ROSED) of a Type 1 Photosensitizer.Proceedings of SPIE--the International Society for Optical Engineering · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. A Monte Carlo simulation for Moving Light Source in Intracavity PDT.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rozhin PenjweiniUniversity of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania, 19104, USA.
Michele M KimUniversity of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania, 19104, USA.
Baochang LiuUniversity of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania, 19104, USA.
Timothy C ZhuUniversity of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania, 19104, USA.
University of Pennsylvania · US

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Image-guided treatment planning for pleural Photodynamic TherapyR01CA154562 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2012 to 2016
$1.6M
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA154562
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is known as a non-invasive treatment modality that is based on photochemical reactions between oxygen, photosensitizer, and a special wavelength of light. However, a dosimetric predictor for PDT outcome is still elusive because current dosimetric quantities do not account for the differences in the PDT oxygen consumption rate for different fluence rates. In this study, we evaluate several dose metrics, total fluence, photobleaching ratio, PDT dose, and mean reacted singlet oxygen (mean [

Indexed as

PhotochemotherapyAnimalsChlorophyllFemaleFibrosarcomaMiceMice, Inbred C3HNeoplasms, Radiation-InducedPhotobleachingPhotosensitizing AgentsSinglet Oxygen2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-aChlorophyllPhotosensitizing AgentsSinglet Oxygencure indexfluenceHPPH-mediated PDTin vivo mice studymean [1O2]rxPDT dosephotobleaching ratio

Identifiers

PMID27653233
PMCPMC5159301
OpenAlexW2522681618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.