Evidence map›Paper›PMID 27653213›Full record

ArticleNature communications2016

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome.

Richard S Beard, Xiaoyuan Yang, Jamie E Meegan, Jonathan W Overstreet, Clement G Y Yang, John A Elliott, Jason J Reynolds, Byeong J Cha, Christopher D Pivetti, David A Mitchell and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. zDHHC21 loss of function activates lung fibroblasts by regulating PTEN palmitoylation.American journal of respiratory cell and molecular biology · 2026
    Article
  3. Review
  4. Article
  5. Article
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  7. Review
  8. Review
  9. Context-dependent roles of palmitoylation in acute respiratory distress syndrome: integrating inflammation, cell death and repair.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential.International journal of cardiology. Heart & vasculature · 2025
    Review
  11. Article
  12. Review
  13. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Richard S BeardDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Xiaoyuan YangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Jamie E MeeganDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Jonathan W OverstreetDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Clement G Y YangDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
John A ElliottDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Jason J ReynoldsDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Byeong J ChaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Christopher D PivettiDepartment of Surgery, School of Medicine, University of California at Davis, Sacramento, California 95817, USA.
David A MitchellDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Mack H WuDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Robert J DeschenesDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
University of South Florida · USUniversity of California, Davis · US

Funding

Microvascular Barrier Dysfunction in Thermal TraumaR01HL070752 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YUAN, SARAH Y · 2002 to 2018
$4.7M
Disintegrin Metalloprotease and Endothelial PermeabilityR01GM097270 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI YUAN, SARAH Y · 2011 to 2020
$2.3M
Neutrophil Activation and Microvascular HyperpermeabilityR01HL126646 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YUAN, SARAH Y · 2016 to 2019
$1.5M
Protein Palmitoylation and the Etiology of X-Linked Intellectual DisabilitiesR21NS090160 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI DESCHENES, ROBERT J · 2016 to 2017
$411k
Molecular Control of Gut Permeability in TraumaI01BX000799 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI WU, MACK H · 2011 to 2023
–
BLRD VA I01 BX000799NHLBI NIH HHS R01 HL070752NHLBI NIH HHS R01 HL126646NIGMS NIH HHS R01 GM097270NINDS NIH HHS R21 NS090160
6 · The paper itself

Abstract

Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation. Pharmacological inhibition of PATs attenuates barrier leakage and leucocyte adhesion induced by endothelial junction hyperpermeability and ICAM-1 expression during inflammation. Among 11 DHHCs detected in vascular endothelium, DHHC21 is required for barrier response. Mice with DHHC21 function deficiency (Zdhhc21

Identifiers

PMID27653213
PMCPMC5036164
OpenAlexW2521862316

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.