ArticleAging2016
Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936.
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Early life predictors of late life cerebral small vessel disease in four prospective cohort studies.Brain : a journal of neurology · 2021Article
- Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.Translational psychiatry · 2021Article
- Understanding the role of the perivascular space in cerebral small vessel disease.Cardiovascular research · 2018Review
- Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936.International journal of epidemiology · 2018Article
- Advanced Neuroimaging of Cerebral Small Vessel Disease.Current treatment options in cardiovascular medicine · 2017Review
- Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936.Neurobiology of aging · 2017Article
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Authors and funding
16 authors.
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Abstract
It is unknown whether relations between early-life factors and overall health in later life apply to burden of cerebral small vessel disease (cSVD), a major cause of stroke and dementia. We explored relations between early-life factors and cSVD in the Lothian Birth Cohort, a healthy aging cohort. Participants were recruited at age 70 (N = 1091); most had completed a test of cognitive ability at age 11 as part of the Scottish Mental Survey of 1947. Of those, 700 participants had brain MRI that could be rated for cSVD conducted at age 73. Presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0-4 representing all MRI cSVD features. We tested associations with early-life factors using multivariate logistic regression. Greater SVD score was significantly associated with lower age-11 IQ (OR higher SVD score per SD age-11 IQ = .78, 95%CI 0.65-.95, p=.01). The associations between SVD score and own job class (OR higher job class, .64 95%CI .43-.95, p=.03), age-11 deprivation index (OR per point deprivation score, 1.08, 95%CI 1.00-1.17, p=.04), and education (OR some qualifying education, .60 95%CI .37-.98, p=.04) trended towards significance (p<.05 for all) but did not meet thresholds for multiple testing. No early-life factor was significantly associated with any one individual score component. Early-life factors may contribute to age-73 burden of cSVD. These relations, and the potential for early social interventions to improve brain health, deserve further study.
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