Evidence map›Paper›PMID 27652886›Full record

ArticleScientific reports2016

Effect of graphene oxide ratio on the cell adhesion and growth behavior on a graphene oxide-coated silicon substrate.

Jin-Tak Jeong, Mun-Ki Choi, Yumin Sim, Jung-Taek Lim, Gil-Sung Kim, Maeng-Je Seong, Jung-Hwan Hyung, Keun Soo Kim, Ahmad Umar, Sang-Kwon Lee

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jin-Tak JeongDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Mun-Ki ChoiDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Yumin SimDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Jung-Taek LimDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Gil-Sung KimDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Maeng-Je SeongDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.
Jung-Hwan HyungDepartment of Semiconductor Science and Technology, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Keun Soo KimDepartment of Physics and Graphene Research Institute, Sejong University, Seoul 143-747, South Korea.
Ahmad UmarDepartment of Chemistry, College of Science and Arts, Najran University, Najran-11001, Kingdom of Saudi Arabia.
Sang-Kwon LeeDepartment of Physics, Chung-Ang University, Seoul 156-756, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Control of living cells on biocompatible materials or on modified substrates is important for the development of bio-applications, including biosensors and implant biomaterials. The topography and hydrophobicity of substrates highly affect cell adhesion, growth, and cell growth kinetics, which is of great importance in bio-applications. Herein, we investigate the adhesion, growth, and morphology of cultured breast cancer cells on a silicon substrate, on which graphene oxides (GO) was partially formed. By minimizing the size and amount of the GO-containing solution and the further annealing process, GO-coated Si samples were prepared which partially covered the Si substrates. The coverage of GO on Si samples decreases upon annealing. The behaviors of cells cultured on two samples have been observed, i.e. partially GO-coated Si (P-GO) and annealed partially GO-coated Si (Annealed p-GO), with a different coverage of GO. Indeed, the spreading area covered by the cells and the number of cells for a given culture period in the incubator were highly dependent on the hydrophobicity and the presence of oxygenated groups on GO and Si substrates, suggesting hydrophobicity-driven cell growth. Thus, the presented method can be used to control the cell growth via an appropriate surface modification.

Identifiers

PMID27652886
PMCPMC5031981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.