Evidence map›Paper›PMID 27652499›Full record

ReviewNature reviews. Rheumatology2016

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk.

Steven R Goldring, Mary B Goldring

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 445 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
445citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06040957 narecruitingnot on this mapstarted 2024, after this paper: background citation

Bone Marrow vs Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis: Randomized Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2024 to 2027Enrolled204ConditionsKnee OsteoarthritisArmsBone marrow aspirate concentrate injection, intra-articular injection of Minimally manipulated adipose tissue
NCT06289218 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Kinesio Taping Versus Interferential Current Therapy in Treating Knee Osteoarthritis: a Comparative Study

TypeinterventionalSponsorCairo UniversityRan2025 to 2025Enrolled63ConditionsKnee OsteoarthritisArmsinterferential current, kinesio taping, exercise
NCT06611774 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Metabolic Syndrome in Patients with Knee Osteoarthritis

TypeobservationalSponsorAssiut UniversityRan2024 to 2027Enrolled174ConditionsKnee Osteoarthritis, Metabolic Syndrome
3 · Its place in the literature

Who cites it

445 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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385 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven R GoldringResearch Division, HSS Research Institute, Hospital for Special Surgery, and Weill Cornell Medical College, 535 East 70th Street, New York, New York 10021, USA.
Mary B GoldringResearch Division, HSS Research Institute, Hospital for Special Surgery, and Weill Cornell Medical College, 535 East 70th Street, New York, New York 10021, USA.

Funding

Defining Common Molecular Parameters For Onset and Progression of OsteoarthritisRC4AR060546 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B, LI, YEFU · 2010 to 2010
$4.1M
Role of ESE1 Regulation of Type II Collagen in CartilageR01AG022021 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B · 2002 to 2014
$3.4M
NIAMS NIH HHS RC4 AR060546NIA NIH HHS R01 AG022021
6 · The paper itself

Abstract

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and trabecular bone form a biocomposite - referred to as the osteochondral unit - that is uniquely adapted to the transfer of load. During the evolution of the osteoarthritic process the compositions, functional properties, and structures of these tissues undergo marked alterations. Although pathological processes might selectively target a single joint tissue, ultimately all of the components of the osteochondral unit will be affected because of their intimate association, and thus the biological and physical crosstalk among them is of great importance. The development of targeted therapies against the osteoarthritic processes in cartilage or bone will, therefore, require an understanding of the state of these joint tissues at the time of the intervention. Importantly, these interventions will not be successful unless they are applied at the early stages of disease before considerable structural and functional alterations occur in the osteochondral unit. This Review describes the changes that occur in bone and cartilage during the osteoarthritic process, and highlights strategies for how this knowledge could be applied to develop new therapeutic interventions for osteoarthritis.

Indexed as

Bone and BonesCancellous BoneCartilage, ArticularChondrocytesDisease ProgressionHumansOsteoarthritisOsteoarthritis, KneeOsteocytes

Identifiers

PMID27652499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.