ArticleJournal of critical care2017
The relationship between executive dysfunction, depression, and mental health-related quality of life in survivors of critical illness: Results from the BRAIN-ICU investigation.
Article in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07035106 (I-WEAR), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
I-WEAR: From ICU to Recovery - Evaluating the Feasibility and Usability of Bi-Weekly Health Summaries Using Wearables in Patients After Intensive Care Unit Treatment - A Pilot Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in health-related quality of life after discharge from an intensive care unit: a systematic review.Anaesthesia · 2019Pooled it
- Current strategies and future directions to enhance recovery following critical illness.Thorax · 2026Review
- Long-term recovery of sensorimotor functions and prediction of participation in survivors of critical illness: a prospective cohort study.Journal of intensive care · 2025Article
- Risk of early death after acute leukemia diagnosis among adolescents and young adults.JNCI cancer spectrum · 2025Article
- Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies.Annals of intensive care · 2025Review
- Self-confidence as a mediator in the relationship between executive functioning and depression among ICU survivors: a latent variable analysis.Critical care (London, England) · 2024Observational
- Long term cognitive dysfunction among critical care survivors: associated factors and quality of life-a multicenter cohort study.Annals of intensive care · 2024Article
- [Research advances on post-burn cognitive disorders and its mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Postacute Sequelae of COVID-19 Critical Illness.Critical care clinics · 2022Review
- Association between the presence of delirium during intensive care unit admission and cognitive impairment or psychiatric problems: the Korean ICU National Data Study.Journal of intensive care · 2022Article
- Researches on cognitive sequelae of burn injury: Current status and advances.Frontiers in neuroscience · 2022Review
- Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study.Journal of intensive care medicine · 2021Observational
- Delirium.Nature reviews. Disease primers · 2020Review
- Challenges in conducting long-term outcomes studies in critical care.Current opinion in critical care · 2019Review
- In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Early Post-Intensive Care Syndrome among Older Adult Sepsis Survivors Receiving Home Care.Journal of the American Geriatrics Society · 2019Article
- Comprehensive care of ICU survivors: Development and implementation of an ICU recovery center.Journal of critical care · 2018Observational
- Aging and Post-Intensive Care Syndrome: A Critical Need for Geriatric Psychiatry.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Review
- Predictors of Major Depressive Disorder following Intensive Care of Chronically Critically Ill Patients.Critical care research and practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeAlthough executive dysfunction and depression are common among intensive care unit (ICU) survivors, their relationship has not been evaluated in this population. We sought to determine (1) if executive dysfunction is independently associated with severity of depressive symptoms or worse mental health-related quality of life (HRQOL) in ICU survivors, and (2) if age modifies these associations.
methodsIn a prospective cohort (n=136), we measured executive dysfunction by the Behavior Rating Inventory of Executive Function-Adult, depression by the Beck Depression Inventory-II, and mental HRQOL by the Short-Form 36. We used multiple linear regression models, adjusting for potential confounders. We included age as an interaction term to test for effect modification.
resultsExecutive dysfunction 3 months post-ICU was independently associated with more depressive symptoms and worse mental HRQOL 12 months post-ICU (25th vs 75th percentile of executive functioning scored 4.3 points worse on the depression scale [95% confidence interval, 1.3-7.4; P=.015] and 5 points worse on the Short-Form 36 [95% confidence interval, 1.7-8.3; P=.006]). Age did not modify these associations (depression: P=.12; mental HRQOL: P=.80).
conclusionRegardless of age, executive dysfunction was independently associated with subsequent worse severity of depressive symptoms and worse mental HRQOL. Executive dysfunction may have a key role in the development of depression.
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Registered trials
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