Evidence map›Paper›PMID 27652379›Full record

ArticleArchivum immunologiae et therapiae experimentalis2017

MAVS is not a Likely Susceptibility Locus for Addison's Disease and Type 1 Diabetes.

Magdalena Zurawek, Marta Fichna, Marta Kazimierska, Piotr Fichna, Agnieszka Dzikiewicz-Krawczyk, Grzegorz Przybylski, Marek Ruchala, Jerzy Nowak

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archivum immunologiae et therapiae experimentalis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Magdalena ZurawekInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland. zurawek@man.poznan.pl.
Marta FichnaInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Marta KazimierskaInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Piotr FichnaDepartment of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
Agnieszka Dzikiewicz-KrawczykInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Grzegorz PrzybylskiInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Marek RuchalaDepartment of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Jerzy NowakInstitute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Polish Academy of Sciences · PLInstitute of Human Genetics · PLPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimmunity. Studies have recently shown variations in genes encoding RLRs as risk factors for autoimmune diseases. We investigated whether MAVS coding polymorphisms are associated with Addison's disease (AD) and type 1 diabetes (T1D) in Polish population. We genotyped 140 AD, 532 T1D patients and 600 healthy controls for MAVS rs17857295, rs7262903, rs45437096 and rs7269320. Genotyping was performed by TaqMan assays. Distribution of the MAVS genotypes and alleles did not reveal significant differences between patients and controls (p > 0.05). This analysis did not indicate the association of the MAVS locus with susceptibility to AD and T1D.

Indexed as

Adaptor Proteins, Signal TransducingAddison DiseaseAdultDiabetes Mellitus, Type 1DNA Mutational AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolandPolymorphism, Single NucleotideRisk FactorsAdaptor Proteins, Signal TransducingMAVS protein, humanAddison’s diseaseMAVSType 1 diabetesVariants

Identifiers

PMID27652379
PMCPMC5434126
OpenAlexW2523178650

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.