Evidence map›Paper›PMID 27652330›Full record

ArticleMolecular & cellular oncology2016

NBR2: A former junk gene emerges as a key player in tumor suppression.

Zhen-Dong Xiao, Xiaowen Liu, Li Zhuang, Boyi Gan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular & cellular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Complex Characterization of Germline Large Genomic Rearrangements of theInternational journal of molecular sciences · 2020
    Article
  9. Article
  10. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  11. Article
  12. Emerging roles of long non-coding RNAs in tumor metabolism.Journal of hematology & oncology · 2018
    Review
  13. Review
  14. Review
  15. Article
  16. Long non-coding RNAs in cancer metabolism.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhen-Dong XiaoDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
Xiaowen LiuDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
Li ZhuangDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
Boyi GanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Studying metabolic stress signaling in renal cancerR01CA181196 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GAN, BOYI · 2014 to 2024
$3.4M
Mechanistic studies of cancer cell adaptive response to PI3K/AKT inhibitionR01CA190370 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GAN, BOYI · 2015 to 2020
$1.8M
NCI NIH HHS R01 CA181196NCI NIH HHS R01 CA190370
6 · The paper itself

Abstract

NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.

Indexed as

AMPKBRCA1energy stress responselncRNANBR2tumor suppression

Identifiers

PMID27652330
PMCPMC4972102
OpenAlexW2396799593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.