Evidence map›Paper›PMID 27652261›Full record

ArticleBioMed research international2016

Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations.

Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Radiological assessment of secondary biliary tree lesions: an update.The Journal of international medical research · 2020
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  15. A case report of gadopentetate dimeglumine-induced cardiac arrest: Resuscitation using extracorporeal membrane oxygenation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
  16. Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023
    Review
  17. Immunotherapy Assessment: A New Paradigm for Radiologists.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vincenza GranataDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.ORCID 0000-0002-6601-3221
Marco CascellaDepartment of Anesthesia, Endoscopy and Cardiology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.ORCID 0000-0002-5236-3132
Roberta FuscoDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Nicoletta dell'AprovitolaDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Orlando CatalanoDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Salvatore FiliceDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Vincenzo SchiavoneUOC Anestesia e Terapia Intensiva, Presidio Ospedaliero "Pineta Grande" Castel Volturno, 81100 Caserta, Italy.
Francesco IzzoDepartment of Hepatobiliary Surgical Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Arturo CuomoDepartment of Anesthesia, Endoscopy and Cardiology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
Antonella PetrilloDepartment of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.ORCID 0000-0002-6074-7670
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITPresidio Ospedaliero · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist). Results. 32 acute adverse reactions occurred, accounting for 0.3% of all administration. Twelve reactions were associated with Gd-DOTA injection (0.11%), 9 with Gd-BOPTA injection (0.08%), 6 with Gd-BTDO3A (0.056%), 3 with Gd-EOB-DTPA (0.028%), and 2 with Gd-DTPA (0.018%). Twenty-four reactions (75.0%) were mild, four (12.5%) moderate, and four (12.5%) severe. The most severe reactions were seen associated with use of Gd-BOPTA, with 3 severe reactions in 32 total reactions. Conclusion. Acute adverse reactions are generally rare with the overall adverse reaction rate of 0.3%. The most common adverse reactions were not severe, consisting in skin rash and hives.

Indexed as

Acute DiseaseAdultAgedAged, 80 and overComorbidityContrast MediaDrug EruptionsDrug-Related Side Effects and Adverse ReactionsFemaleGadoliniumHumansItalyMagnetic Resonance ImagingMaleMiddle AgedNeoplasmsContrast MediaGadolinium

Identifiers

PMID27652261
PMCPMC5019936
OpenAlexW2508729569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.