ReviewTranslational andrology and urology2016
Post orgasmic illness syndrome (POIS).
Review in Translational andrology and urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- A radical approach to treating post-orgasmic illness syndrome: a correspondence.International journal of impotence research · 2026Article
- Artificial intelligence meets medical rarity: evaluating ChatGPT's responses on post-orgasmic illness syndrome.International journal of impotence research · 2025Article
- Postorgasmic Side Effects of Tadalafil: A Case Report.Clinical case reports · 2025Article
- Article
- Associations between masturbation frequency, anxiety, and sleep disturbances during the COVID-19 era.International journal of impotence research · 2025Article
- Recognition and practice patterns of sexual medicine experts towards postorgasmic illness syndrome.International journal of impotence research · 2025Article
- Post orgasmic illness syndrome: a review.International journal of impotence research · 2025Review
- Postorgasmic illness syndrome benefiting from omalizumab and antidepressant: a case report.Journal of medical case reports · 2024Article
- Post-orgasmic Illness Syndrome: A Case Report.Cureus · 2024Article
- A clinical guide to rare male sexual disorders.Nature reviews. Urology · 2024Review
- Case series: expanding diagnostic markers in postorgasmic illness syndrome.Sexual medicine · 2023Article
- The first Tunisian case of postorgasmic illness syndrome: A case report.Clinical case reports · 2021Article
- Article
- Clinical experience with post-orgasmic illness syndrome (POIS) patients-characteristics and possible treatment modality.International journal of impotence research · 2021Observational
- Case of post-orgasmic illness syndrome associated with hypogonadism.IJU case reports · 2020Article
- First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS).International journal of impotence research · 2019Article
- Post orgasmic illness syndrome: what do we know till now?Basic and clinical andrology · 2019Article
- Novel treatment for post-orgasmic illness syndrome: a case report and literature review.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Men with post orgasmic illness syndrome (POIS) become ill rather immediately after ejaculation, whether spontaneously at night, during sexual intercourse or masturbation. Two subtypes are distinguished: primary and secondary POIS. It also occurs before or after a man has been sterilized. POIS is an invalidating most probably auto-immune disease leading to much distress in males and their partners. It is characterized by five criteria. Its symptoms are described by seven clusters. However, the manifestation of these symptoms varies from one male to the other but is relatively constant in the person himself. Among men the symptoms vary in intensity, durations and sort of symptoms. POIS is a chronic disorder that manifests itself in POIS "attacks" that occur within a few minutes to a few hours after ejaculation, and disappear spontaneously after 3 to 7 days. POIS is not associated with increased total serum IgE concentrations. On the contrary, there are indications that POIS is triggered by specific cytokines that are released by an auto-immune reaction to the man's seminal fluid. Indirect clinical evidence suggests that the antigen (Ag) triggering the POIS systemic reaction is not bound to spermatozoa but to seminal fluid produced by prostatic tissue. In addition, POIS may also occur-although rarely-in females. In those cases, it is hypothesized that the Ag is associated with female prostatic tissue around the vagina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.