ArticlePeerJ2016
MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
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- Rare earth elements in biology: From biochemical curiosity to solutions for extractive industries.Microbial biotechnology · 2024Review
- Different lanthanide elements induce strong gene expression changes in a lanthanide-accumulating methylotroph.Microbiology spectrum · 2023Article
- Compartment-related aspects of XoxF protein functionality in Methylorubrum extorquens DM4 analysed using its cytoplasmic targeting.Antonie van Leeuwenhoek · 2023Article
- Identification of a TonB-Dependent Receptor Involved in Lanthanide Switch by the Characterization of Laboratory-Adapted Methylosinus trichosporium OB3b.Applied and environmental microbiology · 2023Article
- Transcriptional Regulation of Methanol Dehydrogenases in the Methanotrophic Bacterium Methylococcus capsulatus Bath by Soluble and Insoluble Lanthanides.Microbes and environments · 2023Article
- Enzymatic properties of alcohol dehydrogenase PedE_M.s. derived fromFrontiers in microbiology · 2023Article
- The effect of lanthanum on growth and gene expression in a facultative methanotroph.Environmental microbiology · 2022Article
- Multispecies Populations of MethanotrophicApplied and environmental microbiology · 2022Article
- Article
- Dehydrogenation Mechanism of Three Stereoisomers of Butane-2,3-Diol inFrontiers in bioengineering and biotechnology · 2021Article
- Gene products and processes contributing to lanthanide homeostasis and methanol metabolism in Methylorubrum extorquens AM1.Scientific reports · 2020Article
- Article
- Novel facultative Methylocella strains are active methane consumers at terrestrial natural gas seeps.Microbiome · 2019Article
- The Chemistry of Lanthanides in Biology: Recent Discoveries, Emerging Principles, and Technological Applications.ACS central science · 2019Review
- Biochemical and Structural Characterization of XoxG and XoxJ and Their Roles in Lanthanide-Dependent Methanol Dehydrogenase Activity.Chembiochem : a European journal of chemical biology · 2019Article
- A Mutagenic Screen Identifies a TonB-Dependent Receptor Required for the Lanthanide Metal Switch in the Type I Methanotroph "Methylotuvimicrobium buryatense" 5GB1C.Journal of bacteriology · 2019Article
- Use of rare-earth elements in the phyllosphere colonizer Methylobacterium extorquens PA1.Molecular microbiology · 2019Article
- Genomics and Biochemistry of Metabolic Pathways for the CIndian journal of microbiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many methylotrophs, microorganisms that consume carbon compounds lacking carbon-carbon bonds, use two different systems to oxidize methanol for energy production and biomass accumulation. The MxaFI methanol dehydrogenase (MDH) contains calcium in its active site, while the XoxF enzyme contains a lanthanide in its active site. The genes encoding the MDH enzymes are differentially regulated by the presence of lanthanides. In this study, we found that the histidine kinase MxaY controls the lanthanide-mediated switch in Methylomicrobium buryatense 5GB1C. MxaY controls the transcription of genes encoding MxaFI and XoxF at least partially by controlling the transcript levels of the orphan response regulator MxaB. We identify a constitutively active version of MxaY, and identify the mutated residue that may be involved in lanthanide sensing. Lastly, we find evidence to suggest that tight control of active MDH production is required for wild-type growth rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.