ArticleCase reports in emergency medicine2016
Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution.
Article in Case reports in emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Integrative taxonomy reveals first record ofBiodiversity data journal · 2024Article
- Acute necrotic arachnidism with necrotising fasciitis and recurrent pneumothorax.BMJ case reports · 2022Article
- Spider bites of medical significance in the Mediterranean area: misdiagnosis, clinical features and management.The journal of venomous animals and toxins including tropical diseases · 2020Review
- Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Brown recluse (BMJ case reports · 2019Article
- Design and Production of a Recombinant Hybrid Toxin to Raise Protective Antibodies AgainstToxins · 2019Article
- Recombinant Phospholipase D from Loxosceles gaucho Binds to Platelets and Promotes Phosphatidylserine Exposure.Toxins · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spider bites are quite frequent and often resolve quickly without leaving outcomes; only some species are capable of causing necrotic and systematic lesions in humans. Among them, we should mention the genus Loxosceles. The venom released from the spider bite of Loxosceles species is composed of proteins, enzymes, and nonenzymatic polypeptides. The phospholipase D family was identified as the active component of the venom. This family of enzymes is responsible for the local and systemic effects observed in loxoscelism. Phospholipases D interact with cell membranes triggering alterations which involve the complement system and activation of neutrophils and they cause the dermonecrotic skin lesions and systemic effects. We describe a fatal case of acute intoxication caused by a spider bite probably belonging to the species Loxosceles. The initial lesion was localized to a finger of a hand. Clinical course was worsening with deep necrotic lesions on limb, shock, hemolysis, acute kidney failure, and disseminated intravascular coagulation. All therapies were ineffective. This is the first fatal case described in Europe.
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Registered trials
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