ArticleDiabetology & metabolic syndrome2016
Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity.
Article in Diabetology & metabolic syndrome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Impact of Maternal Overweight and Obesity on Adipokines During Pregnancy and Lactation.International journal of molecular sciences · 2025Review
- Pathophysiology of Maternal Obesity and Hypertension in Pregnancy.Journal of cardiovascular development and disease · 2025Review
- Influence of Maternal Adipokines on Anthropometry, Adiposity, and Neurodevelopmental Outcomes of the Offspring.International journal of molecular sciences · 2024Review
- Correlation between Overweight, Obesity, Gestational Diabetes Mellitus, Adipokines (Adipolin and Adiponectin), and Adverse Pregnancy Outcomes: A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- Regulation of placental amino acid transport in health and disease.Acta physiologica (Oxford, England) · 2024Review
- Maternal organokines throughout pregnancy as predictors of neonatal anthropometric characteristics and adiposity.Frontiers in endocrinology · 2024Article
- Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines.International journal of molecular sciences · 2023Review
- Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb.Metabolites · 2023Review
- Influence of Pre-Pregnancy Obesity on Carbohydrate and Lipid Metabolism with Selected Adipokines in the Maternal and Fetal Compartment.Nutrients · 2023Article
- Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice.International journal of molecular sciences · 2022Article
- Maternal Metabolic Biomarkers are Associated with Obesity and Excess Gestational Weight Gain.American journal of perinatology · 2021Article
- Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum.Cytokine: X · 2021Article
- Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction.Obstetrics and gynecology clinics of North America · 2021Review
- Predictive role of altered leptin, adiponectin and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid secretion in gestational diabetes mellitus.Experimental and therapeutic medicine · 2021Article
- Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats.American journal of physiology. Heart and circulatory physiology · 2021Article
- Blood level of adipokines and nutritional status variables in adolescent pregnancy.Obstetrics & gynecology science · 2020Article
- Maternal Anthropometric Factors and Circulating Adipokines as Predictors of Birth Weight and Length.International journal of environmental research and public health · 2020Article
- Placental function in maternal obesity.Clinical science (London, England : 1979) · 2020Review
- Key Clinical Factors Predicting Adipokine and Oxidative Stress Marker Concentrations among Normal, Overweight and Obese Pregnant Women Using Artificial Neural Networks.International journal of molecular sciences · 2017Article
- The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity.Nutrients · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal obesity is associated with several adverse pregnancy outcomes. This study was conducted aiming to evaluate maternal levels of adipokines and insulin in pregnancies complicated by overweight and obesity and its correlations with maternal and fetal outcomes.
methodsThis cross-sectional study included 72 mother-newborn pairs. Mothers were classified as having normal weight (n = 23), overweight (n = 18), and obesity (n = 31). Maternal adiponectin, leptin, resistin and insulin levels at the end of pregnancy were compared among groups and correlated with maternal and perinatal outcomes. Data were analyzed by ANOVA and correlation tests, with a p value <0.05 being considered as significant.
resultsObese pregnant women showed higher leptin levels (p = 0.0021). Leptin levels were positively correlated with prepregnancy body mass index-BMI (r = 0.57), gestational (37 or 38 weeks of gestation) BMI (r = 0.39), hypertension (r = 0.27), and hyperglycemia (r = 0.30), and negatively associated with newborns' abdominal circumference (r = -0.25). Adiponectin concentrations were negatively correlated with gestational BMI (r = -0.29) and newborns' cephalic circumference (r = -0.27) and positively correlated with birth weight (r = 0.23). Insulin concentrations correlated positively with prepregnancy BMI (r = 0.38), gestational BMI (r = 0.24) and maternal hyperglycemia (r = 0.26).
conclusionsOur findings support the relationship between markers of obesity and maternal-fetal outcomes. Maternal insulin and adipokines levels showed an independent relationship with mother and newborns outcomes, respectively. In this studied population, the results indirectly reinforce the importance of maternal weight control before and during pregnancy to avoid adverse outcomes to mother and their newborns.
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