Evidence map›Paper›PMID 27651792›Full record

ReviewGastroenterology research and practice2016

Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn's Disease.

Kuan Wang, Lu-Yi Wu, Chuan-Zi Dou, Xin Guan, Huan-Gan Wu, Hui-Rong Liu

Abstract readReview
In one paragraph

Review in Gastroenterology research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Effects of DietaryVeterinary sciences · 2026
    Article
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  3. Article
  4. Review
  5. Review
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  7. Frontiers in pharmacology · 2025
    Article
  8. Article
  9. Drug design, development and therapy · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Effect ofNutrients · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuan WangShanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.ORCID 0000-0002-8282-2002
Lu-Yi WuShanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.ORCID 0000-0001-8888-1698
Chuan-Zi DouShanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
Xin GuanShanghai Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Huan-Gan WuShanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
Hui-Rong LiuShanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.ORCID 0000-0002-5132-1141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the etiology and pathogenesis of Crohn's disease (CD) have not been fully elucidated. It is widely accepted that genetic, immune, and environment factors are closely related to the development of CD. As an important defensive line for human body against the environment, intestinal mucosa is able to protect the homeostasis of gut bacteria and alleviate the intestinal inflammatory and immune response. It is evident that the dysfunction of intestinal mucosa barriers plays a crucial role in CD initiation and development. Yet researches are insufficient on intestinal mucosal barrier's action in the prevention of CD onset. This article summarizes the research advances about the correlations between the disorders of intestinal mucosal barriers and CD.

Identifiers

PMID27651792
PMCPMC5019909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.