ArticleNeural regeneration research2016
Curcumin upregulates S100 expression and improves regeneration of the sciatic nerve following its complete amputation in mice.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Application of PGCL/AP conductive composite scaffold combined with electrical stimulation in neural tissue engineering.Journal of biological engineering · 2026Article
- Effects of systemically administered cholecalciferal and vitamin B complex on mental nerve injury in rats.Scientific reports · 2025Article
- Evaluation of the therapeutic potential of Curcumin and Methylprednisolone in mental nerve injury: a histological and immunohistochemical study in rats.Scientific reports · 2025Article
- Evaluating the Neuroprotective Effects of Levetiracetam on Experimental Sciatic Nerve Injury.Journal of clinical medicine · 2025Article
- Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.International journal of impotence research · 2024Article
- Sustainable Release Selenium Laden with SiOInternational journal of nanomedicine · 2024Article
- The effect of tropisetron on peripheral diabetic neuropathy: possible protective actions against inflammation and apoptosis.Cell stress & chaperones · 2022Article
- The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration.International journal of molecular sciences · 2022Review
- The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature.Cureus · 2022Review
- An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury.Bioactive materials · 2021Article
- Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury.Neural regeneration research · 2021Article
- Effects of tamoxifen therapy on sciatic nerve crush injury: An experimental study in rats.Acta orthopaedica et traumatologica turcica · 2021Article
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
- Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies.Antioxidants (Basel, Switzerland) · 2020Review
- Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.International journal of biological sciences · 2020Review
- Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats.EXCLI journal · 2019Article
- Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repair of peripheral nerve injury after complete amputation is difficult, and even with anastomosis, the rapid recovery of nerve function remains challenging. Curcumin, extracted from plants of the genus Curcuma, has been shown to have anti-oxidant and anti-inflammatory properties and to improve sciatic nerve crush injury in rats. Here, we determined whether curcumin had neuroprotective effects following complete peripheral nerve amputation injury. BALB/c mice underwent complete sciatic nerve amputation, followed by an immediate epineurium anastomosis. Mice were intragastrically administered curcumin at doses of 40 (high), 20 (moderate), and 10 mg/kg/d (low) for 1 week. We found that myelin in the mice of the high- and moderate-dose curcumin groups appeared with regular shape, uniform thickness, clear boundary, and little hyperplasia surrounding the myelin. High and moderate doses of curcumin markedly improved both action potential amplitude of the sciatic nerves and the conduction velocity of the corresponding motor neurons, and upregulated mRNA and protein expression of S100, a marker for Schwann cell proliferation, in L4-6 spinal cord segments. These results suggest that curcumin is effective in promoting the repair of complete sciatic nerve amputation injury and that the underlying mechanism may be associated with upregulation of S100 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.