ArticleMolecular biology and evolution2016
Evolution of Digestive Enzymes and RNASE1 Provides Insights into Dietary Switch of Cetaceans.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 55 citations in OpenAlex.
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- Cetacean tongue mobility and function: A comparative review.Journal of anatomy · 2023Review
- Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla.Science China. Life sciences · 2023Article
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- Convergent evolution of the gut microbiome in marine carnivores.Ecology and evolution · 2022Article
- Diet evolution of carnivorous and herbivorous mammals in Laurasiatheria.BMC ecology and evolution · 2022Article
- Genomic bases underlying the adaptive radiation of core landbirds.BMC ecology and evolution · 2021Article
- Molecular phyloecology suggests a trophic shift concurrent with the evolution of the first birds.Communications biology · 2021Article
- A Single-Step Genome Wide Association Study on Body Size Traits Using Imputation-Based Whole-Genome Sequence Data in Yorkshire Pigs.Frontiers in genetics · 2021Article
- Insights into Dietary Switch in Cetaceans: Evidence from Molecular Evolution of Proteinases and Lipases.Journal of molecular evolution · 2020Article
- Article
- Organization of the Addax Major Histocompatibility Complex Provides Insights Into Ruminant Evolution.Frontiers in immunology · 2020Article
- Signatures of Relaxed Selection in the CYP8B1 Gene of Birds and Mammals.Journal of molecular evolution · 2019Article
- Insights into body size variation in cetaceans from the evolution of body-size-related genes.BMC evolutionary biology · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although cetaceans (whales, porpoises, and dolphins) have multi-chambered stomachs, feeding habits of modern cetaceans have dramatically changed from herbivorous to carnivorous. However, the genetic basis underlying this dietary switch remains unexplored. Here, we present the first systematic investigation of 10 digestive enzymes genes (i.e., CYP7A1, CTRC, LIPC, LIPF, PNLIP, PGC, PRSS1, SI, SLC5A1, and TMPRSS15) of representative cetaceans, and the evolutionary trajectory of RNASE1 in cetartiodactylans. Positive selections were detected with proteinases (i.e., CTRC, PRSS1, and TMPRSS15) and lipases (i.e., CYP7A1, LIPF, and PNLIP) suggesting that cetaceans have evolved an enhanced digestion capacity for proteins and lipids, the major nutritional components of their prey (fishes and invertebrates). In addition, it was found that RNASE1 gene duplicated after the cetartiodactylan speciation and two independent gene duplication events took place in Camelidae and Ruminantia. Positive selection was detected with RNASE1 of Camelidae and Bovidae, suggesting enhanced digestive efficiency in the ruminants. Remarkably, even though the ancestors of cetaceans were terrestrial artiodactyls that are herbivorous, modern cetaceans lost the pancreatic RNASE1 copy with digestive function, which is in accordance with the dietary change from herbivorous to carnivorous. In sum, this is the first study that provides new insights into the evolutionary mechanism of dietary switch in cetaceans.
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