Trial reportScientific reports2016
Neural substrates underlying delusions in schizophrenia.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review.Frontiers in integrative neuroscience · 2021Pooled it
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Reversible Splenial Lesion Syndrome Due to Anti-NMDA Receptor Encephalitis Manifesting as Delusional Disorder: A Case Report and Literature Review.Brain & NeuroRehabilitation · 2026Article
- Elevated glutamine but not glutamate is associated with clozapine eligibility in an early psychosis sample.Frontiers in psychiatry · 2026Article
- Article
- Article
- Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.BMC psychiatry · 2024Article
- Deficit Symptomatology of Schizophrenia Is Associated with Attenuated Taste Identification: Findings from a Cross-Sectional Study.Brain sciences · 2022Article
- Embracing the disharmony in medical imaging: A Simple and effective framework for domain adaptation.Medical image analysis · 2022Article
- Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes.Medical image analysis · 2022Article
- State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients.NeuroImage. Clinical · 2022Article
- White matter microstructure in schizophrenia patients with a history of violence.European archives of psychiatry and clinical neuroscience · 2021Article
- MK-Curve improves sensitivity to identify white matter alterations in clinical high risk for psychosis.NeuroImage · 2021Article
- Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters.Brain imaging and behavior · 2020Article
- Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning.Brain : a journal of neurology · 2020Article
- Article
- Review
- Multisite Machine Learning Analysis Provides a Robust Structural Imaging Signature of Schizophrenia Detectable Across Diverse Patient Populations and Within Individuals.Schizophrenia bulletin · 2018Article
- Understanding Antipsychotic Drug Treatment Effects: A Novel Method to Reduce Pseudospecificity of the Positive and Negative Syndrome Scale (PANSS) Factors.Innovations in clinical neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delusions are cardinal positive symptoms in schizophrenia; however, the neural substrates of delusions remain unknown. In the present study, we investigated the neural correlates of delusions in schizophrenia using multi-modal magnetic resonance imaging (MRI) techniques. Diffusion, structural and perfusion MRIs were performed in 19 schizophrenia patients with severe delusions, 30 patients without delusions and 30 healthy controls. Fractional anisotropy (FA), gray matter volume (GMV) and cerebral blood flow (CBF) were voxel-wisely compared among the three groups. Although patients without delusions exhibited decreased FA in white matter regions and decreased GMV in gray matter regions relative to controls, patients with severe delusions demonstrated comparable FA in all of these white matter regions and similar GMV in most of these gray matter regions. Both patient subgroups had less GMV in the amygdala and anterior cingulate cortex than controls. Although two patient subgroups showed consistent CBF changes relative to controls, only CBF in the anterior cingulate cortex was lower in patients with severe delusions than in patients without delusions. These findings suggest that schizophrenia patients with severe delusions have relatively normal structural integrity. Importantly, the excessively reduced perfusion in the anterior cingulate cortex may be associated with the development of delusions in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.