ArticleScientific reports2016
Biochemical and genome sequence analyses of Megasphaera sp. strain DISK18 from dental plaque of a healthy individual reveals commensal lifestyle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Study of oral microbiome by next generation sequencing in T1DM adolescents with periodontal disease.Acta diabetologica · 2026Article
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- Development of Synthetic Antimicrobial Peptides Based on Genomic Analysis of Streptococcus salivarius.Journal of clinical laboratory analysis · 2025Article
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- Evaluation of Human Dental Plaque Lactic Acid Bacilli for Probiotic Potential and Functional Analysis in Relevance to Oral Health.Indian journal of microbiology · 2023Article
- Microbiome influencers of checkpoint blockade-associated toxicity.The Journal of experimental medicine · 2023Article
- Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.Scientific reports · 2022Article
- Oral Microbiome:Frontiers in microbiology · 2022Article
- Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species.Journal of oral microbiology · 2021Article
- Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study.Frontiers in oral health · 2021Article
- Fecal Bacteria Implicated in Biofilm Production Are Enriched and Associate to Gastrointestinal Symptoms in Patients With APECED - A Pilot Study.Frontiers in immunology · 2021Article
- Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck.Cancer · 2020Article
- Impact of Short-Term Isoflavone Intervention in Polycystic Ovary Syndrome (PCOS) Patients on Microbiota Composition and Metagenomics.Nutrients · 2020Article
- Bacterial Populations in Subgingival Plaque Under Healthy and Diseased Conditions: Genomic Insights into Oral Adaptation Strategies byIndian journal of microbiology · 2020Article
- Role of coaggregation in the pathogenicity and prolonged colonisation of Vibrio cholerae.Medical microbiology and immunology · 2019Article
- Virgicin, a novel lanthipeptide from Virgibacillus sp. strain AK90 exhibits inhibitory activity against Gram-positive bacteria.World journal of microbiology & biotechnology · 2019Article
- Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.Cell host & microbe · 2018Article
- Ecological Shifts of Supragingival Microbiota in Association with Pregnancy.Frontiers in cellular and infection microbiology · 2018Article
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8 authors.
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Abstract
Much of the work in periodontal microbiology in recent years has focused on identifying and understanding periodontal pathogens. As the majority of oral microbes have not yet been isolated in pure form, it is essential to understand the phenotypic characteristics of microbes to decipher their role in oral environment. In this study, strain DISK18 was isolated from gingival sulcus and identified as a Megasphaera species. Although metagenomics studies revealed Megasphaera species as a major group within the oral habitat, they have never been isolated in cultivable form to date. Therefore, we have characterized the DISK18 strain to better understand its role in the periodontal ecosystem. Strain Megasphaera sp. DISK18 displayed the ability to adhere and self-aggregate, which are essential requisite features for inhabiting and persisting in oral cavity. It also coaggregated with other pioneer oral colonizers like Streptococcus and Lactobacillus species but not with Veillonella. This behaviour points towards its role in the ecologic succession of a multispecies biofilm as an early colonizer. The absence of virulence determining genes as observed in whole genome sequence analysis coupled with an inability to degrade collagen reveals that Megasphaera sp. strain DISK18 is likely not a pathogenic species and emphasizes its commensal lifestyle.
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