ArticleScientific reports2016
Circadian dynamics in measures of cortical excitation and inhibition balance.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Epilepsy Occurrence and Circadian Rhythm: A Bibliometrics Study and Visualization Analysis via CiteSpace.Frontiers in neurology · 2020Pooled it
- Baseline Dynamics and Sleep Loss-Driven Changes of Electrocorticographic Aperiodic Properties Are Altered in Mice Lacking Neuroligin-2.The European journal of neuroscience · 2026Article
- Circadian Phase Modulates Embryonic Susceptibility to Bisphenol A-Induced ASD-Related Behavioral Alterations viaToxics · 2026Article
- Causal interhemispheric neuromodulation sharpens synaptic and neurobehavioral inhibition in stroke.Brain communications · 2026Article
- Sleep-dependent alterations in anterior cingulate cortex excitation-inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Region-specific non-rapid eye movement delta activity is associated with stroke recovery.Sleep · 2025Article
- EEG Spectral Exponents and Visual Chirp Responses Mirror Anti-Seizure Medication Load in Refractory Focal Epilepsy.Annals of clinical and translational neurology · 2025Article
- Excitatory/Inhibitory imbalance as a mechanism linking autism and sleep problems.Current opinion in neurobiology · 2025Review
- REM refines and rescues memory representations: a new theory.Sleep advances : a journal of the Sleep Research Society · 2025Review
- Epileptic seizure forecasting with wearable-based nocturnal sleep features.Epilepsia open · 2024Article
- Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature.Clinical neurophysiology practice · 2024Article
- Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment.iScience · 2023Article
- The Effect of Transcranial Electrical Stimulation on the Recovery of Sleep Quality after Sleep Deprivation Based on an EEG Analysis.Brain sciences · 2023Article
- Emotionally clocked out: cell-type specific regulation of mood and anxiety by the circadian clock system in the brain.Frontiers in molecular neuroscience · 2023Review
- The two-process model of sleep regulation: Beginnings and outlook.Journal of sleep research · 2022Review
- Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice.Molecular brain · 2022Article
- Long-Range Amplitude Coupling Is Optimized for Brain Networks That Function at Criticality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.