Evidence map›Paper›PMID 27651084›Full record

ArticleThe international journal of occupational and environmental medicine2016

Micronucleus, Nucleoplasmic Bridge, and Nuclear Budding in Peripheral Blood Cells of Workers Exposed to Low Level Benzene.

I Jamebozorgi, F Mahjoubi, G Pouryaghoub, R Mehrdad, T Majidzadeh, Z Saltanatpour, F Nasiri

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of occupational and environmental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Aberrant DNA Methylation of Two Tumor Suppressor Genes,The international journal of occupational and environmental medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

I JamebozorgiOccupational Medicine Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
F MahjoubiDepartment of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
G PouryaghoubCenter for Research on Occupational Diseases (CROD), Tehran University of Medical Sciences (TUMS), Tehran, Iran. pourya@tums.ac.ir.
R MehrdadCenter for Research on Occupational Diseases (CROD), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
T MajidzadehDepartment of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
Z SaltanatpourDepartment of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
F NasiriCytogenetic Department, Iran Blood Transfusion Organization Research Centre (IBTO), Tehran, Iran.
Tehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBenzene is one of the important occupational pollutants. There are some reports about the leukemogenic effects related to low-level exposure to benzene.

objectiveTo study the frequency of micronucleus (MN), nucleoplasmic bridge (NB), and nuclear budding (NBUD) in the peripheral blood lymphocytes of petrochemical workers with low level exposure to benzene.

methodsWe enrolled 50 workers exposed to low-level benzene and 31 unexposed workers of a petrochemical industry. After exclusion of 3 samples, peripheral blood lymphocytes of the remaining 47 exposed and 31 unexposed workers were analyzed for the frequency of MN, NB, and NBUD by cytochalasin-blocked MN technique.

resultsMN was present in 28 (60%) exposed and 18 (58%) unexposed workers. NB was observed in 6 (13%), and 2 (7%) exposed and unexposed workers, respectively; the frequency for NBUD was 20 (43%), and 13 (42%), respectively. No significant difference was found in the observed frequencies of MN, NB, and NBUD in the peripheral blood lymphocytes between the exposed and unexposed group workers.

conclusionOccupational exposure to low-level benzene does not increase the frequency of MN, NB, and NBUD in the peripheral blood lymphocytes, biomarkers for DNA damage.

Indexed as

Chemical IndustryOil and Gas IndustryAdultBenzeneCase-Control StudiesDNA DamageHumansLymphocytesMaleMicronuclei, Chromosome-DefectiveMicronucleus TestsOccupational ExposureBenzeneBenzeneCell nucleusCytoplasmDNA damageLeukemiaNeoplasms

Identifiers

PMID27651084
PMCPMC6817958
OpenAlexW2521914345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.