Trial reportAmerican journal of ophthalmology2016
Baseline Fourier-Domain Optical Coherence Tomography Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study.
Trial report in American journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Natural Course and Risk Factors of Glaucoma Development in the Untreated Fellow Eye in Unilateral Normal-Tension Glaucoma.Investigative ophthalmology & visual science · 2025Observational
- Percentage macular ganglion cell complex and peripapillary retinal nerve fiber layer loss in different stages of glaucoma.Indian journal of ophthalmology · 2025Article
- Peripapillary Atrophy Area as an Indicator of Glaucomatous Structural and Functional Progression.Translational vision science & technology · 2024Article
- Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma.International journal of ophthalmology · 2024Article
- Which OCT parameters can best predict visual field progression in glaucoma?Eye (London, England) · 2023Article
- Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma.The British journal of ophthalmology · 2023Article
- Long-term reproducibility of optical coherence tomography angiography in healthy and stable glaucomatous eyes.The British journal of ophthalmology · 2023Article
- Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.American journal of ophthalmology · 2023Article
- Ganglion Cell Complex Analysis: Correlations with Retinal Nerve Fiber Layer on Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2023Review
- Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.American journal of ophthalmology · 2022Article
- Rates of Circumpapillary Retinal Nerve Fiber Layer Thinning and Capillary Density Loss in Glaucomatous Eyes with Disc Hemorrhage.American journal of ophthalmology · 2022Observational
- Non-invasive electrophysiology in glaucoma, structure and function-a review.Eye (London, England) · 2021Review
- Rates of Retinal Nerve Fiber Layer Thinning in Distinct Glaucomatous Optic Disc Phenotypes in Early Glaucoma.American journal of ophthalmology · 2021Article
- Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis.Translational vision science & technology · 2021Article
- Risk Factors Associated with Structural Progression in Normal-Tension Glaucoma: Intraocular Pressure, Systemic Blood Pressure, and Myopia.Investigative ophthalmology & visual science · 2020Article
- Measuring Glaucomatous Focal Perfusion Loss in the Peripapillary Retina Using OCT Angiography.Ophthalmology · 2020Observational
- Ganglion Cell Complex Analysis in Glaucoma Patients: What Can It Tell Us?Eye and brain · 2020Review
- Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints.Scientific reports · 2019Article
- Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients.Scientific reports · 2019Observational
- Relationship between intraocular pressure and retinal nerve fibre thickness loss in a monkey model of chronic ocular hypertension.Eye (London, England) · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeTo identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open-angle glaucoma.
designMulticenter cohort study.
methodsParticipants from the Advanced Imaging for Glaucoma (AIG) study were enrolled and followed up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (P < .05) negative slope for VF index (VFI). Fourier-domain optical coherence tomography (FDOCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thickness parameters.
resultsA total of 277 eyes of 188 participants were followed up for 3.7 ± 2.1 years. VF progression was observed in 83 eyes (30%). Several baseline NFL and GCC parameters, but not disc parameters, were found to be significant predictors of progression on univariate Cox regression analysis. The most accurate single predictors were the GCC focal loss volume (FLV), followed closely by NFL-FLV. An abnormal GCC-FLV at baseline increased risk of progression by a hazard ratio of 3.1. Multivariate Cox analysis showed that combining age and central corneal thickness with GCC-FLV in a composite index called "Glaucoma Composite Progression Index" (GCPI) further improved the accuracy of progression prediction. GCC-FLV and GCPI were both found to be significantly correlated with the annual rate of change in VFI.
conclusionFocal GCC and NFL loss as measured by FDOCT are the strongest predictors for VF progression among the measurements considered. Older age and thinner central corneal thickness can enhance the predictive power using the composite risk model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.