SynthesisScientific reports2016
Trauma-specific Grey Matter Alterations in PTSD.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.Brain connectivity · 2023Pooled it
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Neurodegenerative-related gene rescue in anterior insula after early life maltreatment restores adult social interaction in male mice.Molecular psychiatry · 2026Article
- A biobank for complex post-traumatic stress disorder (C-PTSD) and PTSD: study protocol for a cross-sectional study.European journal of psychotraumatology · 2025Article
- Stress-Related Brain Alterations in Chronic Pain.European journal of pain (London, England) · 2025Article
- The value of multimodal neuroimaging in the diagnosis and treatment of post-traumatic stress disorder: a narrative review.Translational psychiatry · 2025Review
- [A study on post-traumatic stress disorder classification based on multi-atlas multi-kernel graph convolutional network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor.NPP - digital psychiatry and neuroscience · 2024Article
- Deep brain stimulation of the subgenual cingulum and uncinate fasciculus for the treatment of posttraumatic stress disorder.Science advances · 2022Article
- Racial discrimination associates with lower cingulate cortex thickness in trauma-exposed black women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Limitations of the protective measure theory in explaining the role of childhood sexual abuse in eating disorders, addictions, and obesity: an updated model with emphasis on biological embedding.Eating and weight disorders : EWD · 2022Review
- Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.Medical hypotheses · 2022Article
- Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake.Frontiers in psychiatry · 2022Article
- Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study.Brain, behavior, & immunity - health · 2021Article
- Variations in response to trauma and hippocampal subfield changes.Neurobiology of stress · 2021Article
- Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity.Journal of psychiatric research · 2021Article
- Gray matter volume correlates of adolescent posttraumatic stress disorder: A comparison of manual intervention and automated segmentation in FreeSurfer.Psychiatry research. Neuroimaging · 2021Article
- The environment contributes more than genetics to smaller hippocampal volume in Posttraumatic Stress Disorder (PTSD).Journal of psychiatric research · 2021Article
- Hippocampal subfield alterations in pediatric patients with post-traumatic stress disorder.Social cognitive and affective neuroscience · 2021Article
- Transcriptomic organization of the human brain in post-traumatic stress disorder.Nature neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that patients with posttraumatic stress disorder (PTSD) caused by different types of trauma may show divergence in epidemiology, clinical manifestation and treatment outcome. However, it is still unclear whether this divergence has neuroanatomic correlates in PTSD brains. To elucidate the general and trauma-specific cortical morphometric alterations, we performed a meta-analysis of grey matter (GM) changes in PTSD (N = 246) with different traumas and trauma-exposed controls (TECs, N = 347) using anisotropic effect-size signed differential mapping and its subgroup analysis. Our results revealed general GM reduction (GMR) foci in the prefrontal-limbic-striatal system of PTSD brains when compared with those of TECs. Notably, the GMR patterns were trauma-specific. For PTSD by single-incident traumas, GMR foci were found in bilateral medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), insula, striatum, left hippocampus and amygdala; and for PTSD by prolonged traumas in the left insula, striatum, amygdala and middle temporal gyrus. Moreover, Clinician-Administered PTSD Scale scores were found to be negatively associated with the GM changes in bilateral ACC and mPFC. Our study indicates that the GMR patterns of PTSD are associated with specific traumas, suggesting a stratified diagnosis and treatment for PTSD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.