ArticlePharmaceutical biology2017
Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedToxicological research · 2019Article
- Pleurotus ostreatus extract inhibits Eimeria species development in naturally infected broiler chickens.Tropical animal health and production · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextControl of African trypanosomiasis relies on chemotherapy, but the development of resistance and the problem of drug residues require research for alternatives. Triterpenes and phenolics, the major constituents of Pleurotus sajor-caju (Fr.) Singer (Pleurotaceae), are reported to be effective against trypanosomiasis.
objectiveTrypanocidal effect of whole Pleurotus sajor-caju aqueous extract was investigated in vivo against Trypanosoma congolense. MATERIALS AND
methodsMice (25-32 g) were divided into seven groups of six animals. Mice in groups A-F received 2.5 × 10
resultsParasitemia decreased significantly (p < 0.01) post-treatment with 200 and 250 mg/kg of the extract and became undetectable by day 16 and 12 post-infection, respectively; the ED
conclusionPleurotus sajor-caju therefore could be a potential source of new trypanocidal drugs.
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Registered trials
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