Evidence map›Paper›PMID 27650668›Full record

ReviewJournal of the American Medical Directors Association2017

The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge.

Alessandro Morandi, Daniel Davis, Giuseppe Bellelli, Rakesh C Arora, Gideon A Caplan, Barbara Kamholz, Ann Kolanowski, Donna Marie Fick, Stefan Kreisel, Alasdair MacLullich and 11 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American Medical Directors Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Agitation Severity and Psychotropic Prescription in Acute Patients With Delirium Superimposed on Dementia.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
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  12. Observational
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 8 countries.

Alessandro MorandiDepartment of Rehabilitation and Aged Care of the Fondazione Camplani, Ancelle Hospital, Cremona, Italy; Geriatric Research Group, Brescia, Italy. Electronic address: morandi.alessandro@gmail.com.
Daniel DavisUniversity College London, London, United Kingdom.
Giuseppe BellelliGeriatric Research Group, Brescia, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, and Geriatric Unit, San Gerardo hospital, Monza, Italy.
Rakesh C AroraDepartment of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba Canada; Cardiac Sciences Program, St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Gideon A CaplanDepartment of Geriatric Medicine, Prince of Wales Hospital, Sydney, Australia Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Barbara KamholzDepartment of Psychiatry, University of California at San Francisco, San Francisco, CA.
Ann KolanowskiCollege of Nursing and College of Medicine, The Pennsylvania State University, University Park, PA.
Donna Marie FickPenn State College of Nursing, The Pennsylvania State University, University Park, PA.
Stefan KreiselDepartment of Psychiatry and Psychotherapy, Bethel EvangelischesKrankenhaus, Bielefeld, Germany.
Alasdair MacLullichEdinburgh Delirium Research Group, University of Edinburgh, Edinburgh, United Kingdom.
David MeagherGraduate-entry Medical School, Cognitive Impairment Research Group, Center for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, Limerick, Ireland.
Karen NeufeldDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD.
Pratik P PandharipandeDepartment of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, and the Anesthesia Service, Department of Veterans Affairs, Tennessee Valley Healthcare System.
Sarah RichardsonInstitute of Neuroscience, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
Arjen J C SlooterDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
John P TaylorCampus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
Christine ThomasDepartment of Psychiatry and Psychotherapy of the Aged, Center of Mental Health, Klinikum Stuttgart, Germany.
Zoë TiegesEdinburgh Delirium Research Group, University of Edinburgh, Edinburgh, United Kingdom.
Andrew TeodorczukSchool of Medicine and Health Institute for the Development of Education and Scholarship (HEALTH IDEAS), Griffith University, Queensland, Australia.
Philippe VoyerLaval University, Quebec City, Canada Center for Excellence in Aging-Research Unit, Quebec City, Canada.
James L RudolphCenter of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI; Warren Alpert School of Medicine at Brown University, Providence, RI.
Newcastle University · GBPennsylvania State University · USUniversity of Edinburgh · GBBrown University · USEvangelisches Krankenhaus Bielefeld · DEGriffith University · AUGruppo di Ricerca Geriatrica · ITJohns Hopkins University · USKlinikum Stuttgart · DEUniversité Laval · CAUniversity College London · GBUniversity Medical Center Utrecht · NLUniversity of California, San Francisco · USUniversity of Limerick · IEUniversity of Manitoba · CAUniversity of Milano-Bicocca · ITUNSW Sydney · AUVanderbilt University · US

Funding

READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Medical Research Council MC_UU_12019/1Medical Research Council MR/K026992/1NIA NIH HHS R01 AG030618Wellcome Trust 107467/Z/15/Z
6 · The paper itself

Abstract

Delirium occurring in patients with dementia is referred to as delirium superimposed on dementia (DSD). People who are older with dementia and who are institutionalized are at increased risk of developing delirium when hospitalized. In addition, their prior cognitive impairment makes detecting their delirium a challenge. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the International Statistical Classification of Diseases and Related Health Problems, 10th Revision are considered the standard reference for the diagnosis of delirium and include criteria of impairments in cognitive processes such as attention, additional cognitive disturbances, or altered level of arousal. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the International Statistical Classification of Diseases and Related Health Problems, 10th Revision does not provide guidance regarding specific tests for assessment of the cognitive process impaired in delirium. Importantly, the assessment or inclusion of preexisting cognitive impairment is also not addressed by these standards. The challenge of DSD gets more complex as types of dementia, particularly dementia with Lewy bodies, which has features of both delirium and dementia, are considered. The objective of this article is to critically review key elements for the diagnosis of DSD, including the challenge of neuropsychological assessment in patients with dementia and the influence of particular tests used to diagnose DSD. To address the challenges of DSD diagnosis, we present a framework for guiding the focus of future research efforts to develop a reliable reference standard to diagnose DSD. A key feature of a reliable reference standard will improve the ability to clinically diagnose DSD in facility-based patients and research studies.

Indexed as

ComorbidityDementiaDeliriumHumansNeuropsychological TestsAlzheimer diseaseDeliriumdelirium superimposed on dementiadementiadiagnosisLewy Body dementia

Identifiers

PMID27650668
PMCPMC5373084
OpenAlexW2520051178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.