Evidence map›Paper›PMID 27650530›Full record

ArticlePurinergic signalling2016

Adenosine A

Aurora R Barros-Barbosa, Fátima Ferreirinha, Ângela Oliveira, Marina Mendes, M Graça Lobo, Agostinho Santos, Rui Rangel, Julie Pelletier, Jean Sévigny, J Miguel Cordeiro and 1 more

Abstract read
In one paragraph

Article in Purinergic signalling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Dual CD73/AFrontiers in pharmacology · 2026
    Article
  3. Review
  4. Upregulation of adenosine AMolecular psychiatry · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Adenosine ABiomolecules · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Adenosine AScientific reports · 2022
    Article
  16. Article
  17. Association Between Adenosine AMolecular neurobiology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Aurora R Barros-BarbosaLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Fátima FerreirinhaLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Ângela OliveiraLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Marina MendesLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
M Graça LoboLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Agostinho SantosServiço de Patologia Forense, Instituto Nacional de Medicina Legal e Ciências Forenses-Delegação do Norte (INMLCF-DN), Porto, Portugal.
Rui RangelServiço de Neurocirurgia, Centro Hospitalar do Porto-Hospital Geral de Santo António (CHP-HGSA), Porto, Portugal.
Julie PelletierCentre de Recherche du CHU de Québec-Université Laval, CHUL, QC, Québec, Canada.
Jean SévignyCentre de Recherche du CHU de Québec-Université Laval, CHUL, QC, Québec, Canada.
J Miguel CordeiroLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Paulo Correia-de-SáLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. farmacol@icbas.up.pt.ORCID 0000-0002-6114-9189
Universidade do Porto · PTCentre hospitalier de l'Université Laval · CAHospital de Santo António · PTNational Legal Medicine Institute · PT

Funding

CIHR MOP-102472CIHR MOP-93683
6 · The paper itself

Abstract

Refractoriness to existing medications of up to 80 % of the patients with mesial temporal lobe epilepsy (MTLE) prompts for finding new antiepileptic drug targets. The adenosine A

Indexed as

Up-Regulation5'-NucleotidaseAdultAgedAstrocytesEpilepsy, Temporal LobeFemaleGlial Fibrillary Acidic ProteinHippocampusHumansMaleMiddle AgedReceptor, Adenosine A2A5'-NucleotidaseGlial Fibrillary Acidic ProteinReceptor, Adenosine A2AAdenosine A2A receptorAntiepileptic drugsAstrogliosisEcto-5′-nucleotidase/CD73Human hippocampusMesial temporal lobe epilepsy (MTLE)

Identifiers

PMID27650530
PMCPMC5124012
OpenAlexW2523043011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.