Evidence map›Paper›PMID 27650414›Full record

ArticleCancer medicine2016

Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma.

Jiang Chen, Yaojun Yu, Tong Ji, Rui Ma, Mingming Chen, Gaofeng Li, Feibo Li, Qiong Ding, Qingsong Kang, Diyu Huang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Kelch-like proteins in the gastrointestinal tumors.Acta pharmacologica Sinica · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. NRF2 addiction in cancer cells.Cancer science · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jiang ChenDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Yaojun YuDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Tong JiDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Rui MaDepartment of Surgery, Zhejiang University Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Mingming ChenDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Gaofeng LiLife Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang, China.
Feibo LiDepartment of General Surgery, Zhejiang Putuo hospital, zhoushan, Zhejiang, China.
Qiong DingDepartment of General Surgery, Zhejiang Putuo hospital, zhoushan, Zhejiang, China.
Qingsong KangDepartment of General Surgery, Zhejiang Putuo hospital, zhoushan, Zhejiang, China.
Diyu HuangDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Xiao LiangDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Hui LinDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Xiujun CaiDepartment of General Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang, China. cxjzu@hotmail.com.
Zhejiang University · CNZhejiang Hospital · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, variation tendency of phosphorylated Nrf2, as the activated form of native Nrf2, was studied in 107 primary hepatocellular carcinoma (HCC) specimens treated by curative hepatectomy. Moreover, the coexpression of oxidative stress markers Keap1 and pNrf2, and their association with pathological features were also evaluated based on those specimens. The results showed that preserved cytoplasmic Keap1 expression of cancer cells was observed in 59 HCCs, while reduced Keap1 expression was determined in remaining 48 ones. With regarding to nuclear pNrf2 expression, 75 HCCs were defined as high and the other 32 ones as low. There was a significant association between Keap1 and pNrf2 expression in HCCs. Higher pNrf2 expression was observed, at a more substantial proportion, in those specimens with reduced Keap1 expression, compared to those with preserved Keap1 expression. The subset with higher pNrf2 and reduced Keap1 expression was defined as pNrf2

Indexed as

AdolescentAdultAgedAged, 80 and overCarcinoma, HepatocellularCell NucleusCytoplasmFemaleGene Expression Regulation, NeoplasticHepatectomyHumansKelch-Like ECH-Associated Protein 1Liver NeoplasmsMaleMiddle AgedNF-E2-Related Factor 2KEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2Hepatocellular carcinomaKeap1Oxidative stressphosphorylated Nrf2 (pNrf2)prognosis

Identifiers

PMID27650414
PMCPMC5083719
OpenAlexW2523200795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.