ArticleOrganic letters2016
Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine.
Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Random Forest Modeling to Predict Small Molecule Accumulation in Gram-Negative Bacteria.ACS infectious diseases · 2026Article
- Divergent and precise alkaloid remodelling with a small suite of reactions.Nature chemistry · 2026Article
- Identification of a Selective Anticancer Agent from a Collection of Complex-And-Diverse Compounds Synthesized from Stevioside.Journal of the American Chemical Society · 2025Article
- Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives.Current medicinal chemistry · 2025Review
- Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents.Organic & biomolecular chemistry · 2024Article
- Machine Learning Prediction of Quantum Yields and Wavelengths of Aggregation-Induced Emission Molecules.Materials (Basel, Switzerland) · 2024Article
- Skeletal diversification by C-C cleavage to access bicyclic frameworks from a common tricyclooctane intermediate.Chemical communications (Cambridge, England) · 2023Article
- Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.Journal of the American Chemical Society · 2022Article
- Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries.Molecules (Basel, Switzerland) · 2022Review
- Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents.ACS omega · 2021Article
- Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity.Angewandte Chemie (International ed. in English) · 2021Article
- Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.Accounts of chemical research · 2021Review
- Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids.Nature communications · 2021Article
- Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior ofDrug delivery · 2020Article
- Re-engineering natural products to engage new biological targets.Natural product reports · 2020Article
- Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity.Journal of medicinal chemistry · 2020Article
- Re-Engineering of Yohimbine's Biological Activity through Ring Distortion: Identification and Structure-Activity Relationships of a New Class of Antiplasmodial Agents.ACS infectious diseases · 2020Article
- Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.Journal of medicinal chemistry · 2019Review
- Natural Products as a Foundation for Drug Discovery.Current protocols in pharmacology · 2019Review
- Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.Nature chemistry · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many compound collections used in high-throughput screening are composed of members whose structural complexity is considerably lower than that of natural products. We previously reported a strategy for the synthesis of complex and diverse small molecules from natural products using ring-distortion reactions, called complexity-to-diversity (CtD), and herein, CtD is applied in the synthesis of 16 diverse scaffolds and 65 total compounds from the alkaloid natural product sinomenine. Chemoinformatic analysis shows that these compounds possess complex ring systems and marked three-dimensionality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.