ArticleScientific reports2016
Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Focusing optical phased array for tissue interrogation with improved side-lobe suppression and simplified beam steering.Biomedical optics express · 2026Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Assessment of Murine Retinal Acuity Ex Vivo Using Multielectrode Array Recordings.Translational vision science & technology · 2023Article
- Retinal Processing: Insights from Mathematical Modelling.Journal of imaging · 2022Article
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- Pluripotent Stem Cell-Based Organoid Technologies for Developing Next-Generation Vision Restoration Therapies of Blindness.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2021Review
- Towards optogenetic vision restoration with high resolution.PLoS computational biology · 2020Article
- Restoring vision at the fovea.Current opinion in behavioral sciences · 2019Article
- A head mounted device stimulator for optogenetic retinal prosthesis.Journal of neural engineering · 2018Article
- Restoring Vision to the Blind with Chemical Photoswitches.Chemical reviews · 2018Review
- Development of visual Neuroprostheses: trends and challenges.Bioelectronic medicine · 2018Review
- Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment.Frontiers in cellular neuroscience · 2018Article
- Restoring visual function to the blind retina with a potent, safe and long-lasting photoswitch.Scientific reports · 2017Article
- Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin.Molecular vision · 2017Article
- Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity.Journal of experimental neuroscience · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Retinitis pigmentosa is a progressive retinal dystrophy that causes irreversible visual impairment and blindness. Retinal prostheses currently represent the only clinically available vision-restoring treatment, but the quality of vision returned remains poor. Recently, it has been suggested that the pathological spontaneous hyperactivity present in dystrophic retinas may contribute to the poor quality of vision returned by retinal prosthetics by reducing the signal-to-noise ratio of prosthetic responses. Here, we investigated to what extent blocking this hyperactivity can improve optogenetic retinal prosthetic responses. We recorded activity from channelrhodopsin-expressing retinal ganglion cells in retinal wholemounts in a mouse model of retinitis pigmentosa. Sophisticated stimuli, inspired by those used in clinical visual assessment, were used to assess light sensitivity, contrast sensitivity and spatial acuity of optogenetic responses; in all cases these were improved after blocking spontaneous hyperactivity using meclofenamic acid, a gap junction blocker. Our results suggest that this approach significantly improves the quality of vision returned by retinal prosthetics, paving the way to novel clinical applications. Moreover, the improvements in sensitivity achieved by blocking spontaneous hyperactivity may extend the dynamic range of optogenetic retinal prostheses, allowing them to be used at lower light intensities such as those encountered in everyday life.
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