ArticleNature communications2016
Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Transcriptomic analysis of oriental tea tortrix infected with male-killing virus.Molecular biology reports · 2026Article
- Analysis of the genomes of a male-killingMicrobial genomics · 2026Article
- Spiroplasma Display an Intricate Continuum of Infection Heterogeneity and Persistence in Myrmica Ants.Molecular ecology · 2026Article
- Diverse toxin repertoire but limited metabolic capacities inferred from the draft genome assemblies of threeMicrobial genomics · 2025Article
- Elucidating the Molecular Mechanisms of Sex Ratio Distortion Mediated by Cytoplasmic Symbionts.Genome biology and evolution · 2025Review
- Symbiotic bacteria associated with different species ofFrontiers in microbiology · 2025Article
- Bioinformatics analysis of the Microsporidia sp. MB genome: a malaria transmission-blocking symbiont of the Anopheles arabiensis mosquito.BMC genomics · 2024Article
- Geographical, Seasonal, and Growth-Related Dynamics of Gut Microbiota in a Grapevine Pest, Apolygus spinolae (Heteroptera: Miridae).Microbial ecology · 2024Article
- Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality.Science (New York, N.Y.) · 2024Article
- Maintenance and Evaluation of Wolbachia Male-Killers of Dipterans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima.Applied and environmental microbiology · 2023Article
- Article
- Host plant-mediated effects onFrontiers in plant science · 2023Article
- Cell-based analysis reveals that sex-determining gene signals inPNAS nexus · 2023Article
- Natural and Engineered Sex Ratio Distortion in Insects.Frontiers in ecology and evolution · 2022Article
- Sex determination systems as the interface between male-killing bacteria and their hosts.Proceedings. Biological sciences · 2022Review
- Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis.PLoS pathogens · 2021Article
- Mechanistically comparing reproductive manipulations caused by selfish chromosomes and bacterial symbionts.Heredity · 2021Review
- Wolbachia and Spiroplasma could influence bacterial communities of the spider mite Tetranychus truncatus.Experimental & applied acarology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Some symbiotic bacteria are capable of interfering with host reproduction in selfish ways. How such bacteria can manipulate host's sex-related mechanisms is of fundamental interest encompassing cell, developmental and evolutionary biology. Here, we uncover the molecular and cellular mechanisms underlying Spiroplasma-induced embryonic male lethality in Drosophila melanogaster. Transcriptomic analysis reveals that many genes related to DNA damage and apoptosis are up-regulated specifically in infected male embryos. Detailed genetic and cytological analyses demonstrate that male-killing Spiroplasma causes DNA damage on the male X chromosome interacting with the male-specific lethal (MSL) complex. The damaged male X chromosome exhibits a chromatin bridge during mitosis, and bridge breakage triggers sex-specific abnormal apoptosis via p53-dependent pathways. Notably, the MSL complex is not only necessary but also sufficient for this cytotoxic process. These results highlight symbiont's sophisticated strategy to target host's sex chromosome and recruit host's molecular cascades toward massive apoptosis in a sex-specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.