Evidence map›Paper›PMID 27650263›Full record

ReviewThe ocular surface2017

Current and Upcoming Therapies for Ocular Surface Chemical Injuries.

Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian

2 registry-linked trialsAbstract readReview
In one paragraph

Review in The ocular surface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626583 phase1completednot on this mapstarted 2021, after this paper: background citation

Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells for Promoting Corneal Repair

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2021 to 2023Enrolled8ConditionsMesenchymal Stromal Cells, Cornea, Safety, Corneal DefectArmsAllogeneic MSC
NCT05705024 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy of Locally Delivered Allogeneic Mesenchymal Stem Cells for Promoting Corneal Repair

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2023 to 2026Enrolled38ConditionsCorneal UlcerArmsMesenchymal Stromal Cells, Control Solution
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.

  1. Role of Neutrophils on the Ocular Surface.International journal of molecular sciences · 2021
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Sodium Amide Eye Injury: Eye Injury After Sodium Amide Explosion.Case reports in ophthalmological medicine · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review of the 100 Most Cited Articles inEuropean burn journal · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alireza Baradaran-RafiiOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medi EslaniDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Zeeshan HaqDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Ebrahim ShirzadehOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Michael J HuvardDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Ali R DjalilianDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: adjalili@uic.edu.
University of Illinois Chicago · USShahid Beheshti University of Medical Sciences · IR

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8M
UIC K12 Independent Clinical Vision Scientist Development ProgramK12EY021475 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALI R DJALILIAN, CHARLOTTE E JOSLIN · 2011 to 2026
$6.7M
Novel Therapies for Ocular Chemical InjuriesR01EY024349 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DJALILIAN, ALI R · 2015 to 2020
$2.1M
NEI NIH HHS K12 EY021475NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY024349
6 · The paper itself

Abstract

Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries.

Indexed as

Eye InjuriesBurns, ChemicalHumansLimbus CorneaeStem Cell TransplantationTreatment Outcomechemical burncornealimbal stem cell deficiencyocular chemical burnocular surfacestem cell

Identifiers

PMID27650263
PMCPMC5191942
OpenAlexW2520097406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.