ArticleHuman mutation2017
Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Human mutation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00461188 (Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA), which is not on this map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Irish giants: from myth to medicine.Irish journal of medical science · 2026Article
- Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.European journal of endocrinology · 2025Article
- Early Onset GH Excess: Somatotroph Adenoma in a Young Adult.JCEM case reports · 2023Article
- Genetics of Acromegaly and Gigantism.Journal of clinical medicine · 2021Review
- AIP variant causing familial prolactinoma.Pituitary · 2021Article
- Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future.Frontiers in endocrinology · 2021Review
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Phosphodiesterases and cAMP Pathway in Pituitary Diseases.Frontiers in endocrinology · 2019Review
- The causes and consequences of pituitary gigantism.Nature reviews. Endocrinology · 2018Review
- Medical Myths and Legends: Presidential Address to the Ulster Medical Society. 6th October 2016.The Ulster medical journal · 2018Article
- Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland.Oncotarget · 2018Article
- Three Reportedly Unrelated Families With Liddle Syndrome Inherited From a Common Ancestor.Hypertension (Dallas, Tex. : 1979) · 2018Article
- In-frame seven amino-acid duplication inEuropean journal of endocrinology · 2017Observational
- The genetic background of acromegaly.Pituitary · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 8 countries.
Serban RadianCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Yoan DiekmannResearch Department of Genetics, Evolution and Environment, University College London, London, UK.
Plamena GabrovskaCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Brendan HollandCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lisa BradleyDepartment of Medical Genetics, Belfast HSC Trust, Belfast, UK.
Helen WallaceRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK.
Karen StalsDepartment of Molecular Genetics, Royal Devon and Exeter NHS Foundation Trust/ Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Anna-Marie BussellDepartment of Molecular Genetics, Royal Devon and Exeter NHS Foundation Trust/ Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Karen McGurrenDepartment of Endocrinology and Diabetes, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.
Martin CuestaDepartment of Endocrinology and Diabetes, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.
Anthony W RyanDepartment of Clinical Medicine and Institute of Molecular Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
Maria HerincsCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Laura C Hernández-RamírezCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Aidan HollandCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jade SamuelsCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Elena Daniela AfloreiCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sayka BarryCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Judit DénesCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ida PernicovaCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Craig E StilesCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Giampaolo TrivellinCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ronan McCloskeyCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Michal AjzensztejnRoyal Belfast Hospital for Sick Children, Belfast, UK.
Noina AbidRoyal Belfast Hospital for Sick Children, Belfast, UK.
Scott A AkkerCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Moises MercadoEndocrinology Service/Experimental Endocrinology Unit, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
Mark CohenDepartment of Endocrinology and Diabetes, Barnet General Hospital, London, UK.
Rajesh V ThakkerAcademic Endocrine Unit, OCDEM, University of Oxford, Oxford, UK.
Stephanie BaldewegDepartment of Endocrinology and Diabetes, University College London Hospitals, London, UK.
Ariel BarkanDepartment of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
Madalina MusatDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Miles LevyDepartment of Endocrinology, University Hospitals of Leicester, Leicester, UK.
Stephen M OrmeDepartment of Endocrinology, St James's University Hospital, Leeds, UK.
Martina UnterländerInstitute of Anthropology, Johannes Gutenberg University, Mainz, Germany.
Joachim BurgerInstitute of Anthropology, Johannes Gutenberg University, Mainz, Germany.
Ajith V KumarNorth East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK.
Sian EllardDepartment of Molecular Genetics, Royal Devon and Exeter NHS Foundation Trust/ Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Joseph McPartlinTrinity Biobank, Institute of Molecular Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
Ross McManusDepartment of Clinical Medicine and Institute of Molecular Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
Gerard J LindenCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Brew AtkinsonRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK.
David J BaldingResearch Department of Genetics, Evolution and Environment, University College London, London, UK.
Amar AghaDepartment of Endocrinology and Diabetes, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.
Chris J ThompsonDepartment of Endocrinology and Diabetes, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.
Steven J HunterRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK.
Mark G ThomasResearch Department of Genetics, Evolution and Environment, University College London, London, UK.
Patrick J MorrisonDepartment of Medical Genetics, Belfast HSC Trust, Belfast, UK.
Márta KorbonitsCentre of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Queen Mary University of London · GBWilliam Harvey Research Institute · GBBeaumont Hospital · IEUniversity College London · GBBelfast Health and Social Care Trust · GBJohannes Gutenberg University Mainz · DERoyal Belfast Hospital for Sick Children · GBRoyal Devon & Exeter NHS Foundation Trust · GBRoyal Victoria Hospital · GBTrinity College Dublin · IEBarnet Hospital · GBCarol Davila University of Medicine and Pharmacy · ROHospital de Especialidades · MXQueen's University Belfast · GBSt. James's Hospital · IESt James's University Hospital · GBUniversity College Hospital · GBUniversity of Exeter · GBUniversity of Leicester · GBUniversity of Melbourne · AU
Funding
Medical Research Council G1000467Medical Research Council MR/M018539/1MRF_ C0467Wellcome TrustWellcome Trust 097970/Z/11/ZWellcome Trust 098395/Z/12/AWellcome Trust 100719/Z/12/Z
Abstract
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304
Indexed as
Genetic Predisposition to DiseaseAcromegalyAdolescentAdultAgedAged, 80 and overAllelesAmino Acid SubstitutionChromosome MappingCross-Sectional StudiesFemaleGene FrequencyGenotypeGigantismHeterozygoteHumansaryl hydrocarbon receptor-interacting proteinIntracellular Signaling Peptides and Proteinsacromegaly and gigantismAIPevolutionary geneticsfounder mutationpopulation screening
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT00461188ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.