ArticleScientific reports2016
Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson's disease examined using persistent homology-based analysis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.Nature communications · 2024Article
- Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats.International journal of molecular sciences · 2024Article
- Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity.Journal of neuroinflammation · 2023Article
- Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder.Psychiatry investigation · 2022Article
- Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice.Frontiers in behavioral neuroscience · 2022Article
- Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson's Disease.Frontiers in synaptic neuroscience · 2021Article
- Changes in brain glucose metabolism and connectivity in somatoform disorders: anEuropean archives of psychiatry and clinical neuroscience · 2020Article
- Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.Frontiers in aging neuroscience · 2020Article
- Clinical Personal Connectomics Using Hybrid PET/MRI.Nuclear medicine and molecular imaging · 2019Article
- Topological exploration of artificial neuronal network dynamics.Network neuroscience (Cambridge, Mass.) · 2019Article
- Disrupted Resting State Network of Fibromyalgia in Theta frequency.Scientific reports · 2018Article
- Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity.Oxidative medicine and cellular longevity · 2018Article
- Osteocalcin Ameliorates Motor Dysfunction in a 6-Hydroxydopamine-Induced Parkinson's Disease Rat Model Through AKT/GSK3β Signaling.Frontiers in molecular neuroscience · 2018Article
- Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated InflammationFrontiers in molecular neuroscience · 2017Article
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9 authors at 1 institution in 1 country.
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Abstract
Movement impairments in Parkinson's disease (PD) are caused by the degeneration of dopaminergic neurons and the consequent disruption of connectivity in the cortico-striatal-thalamic loop. This study evaluated brain metabolic connectivity in a 6-Hydroxydopamine (6-OHDA)-induced mouse model of PD using (18)F-fluorodeoxy glucose positron emission tomography (FDG PET). Fourteen PD-model mice and ten control mice were used for the analysis. Voxel-wise t-tests on FDG PET results yielded no significant regional metabolic differences between the PD and control groups. However, the PD group showed lower correlations between the right caudoputamen and the left caudoputamen and right visual cortex. Further network analyses based on the threshold-free persistent homology framework revealed that brain networks were globally disrupted in the PD group, especially between the right auditory cortex and bilateral cortical structures and the left caudoputamen. In conclusion, regional glucose metabolism of PD was preserved, but the metabolic connectivity of the cortico-striatal-thalamic loop was globally impaired in PD.
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