Evidence map›Paper›PMID 27649978›Full record

ArticleIn vitro cellular & developmental biology. Animal2017

A potential inhibitory function of draxin in regulating mouse trunk neural crest migration.

Sanbing Zhang, Yuhong Su, Jinbao Gao, Chenbing Zhang, Hideaki Tanaka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sanbing ZhangDepartment of Hand and Foot Surgery, The Third Hospital of Shijiazhuang City, 15 South Tiyu Street, Shijiazhuang, 050000, People's Republic of China. zhangsanfeng80@hotmail.com.
Yuhong SuDepartment of Human Anatomy, Hebei Medical University, No. 361 East Zhongshan Road, Shijiazhuang, Hebei Province, 050017, People's Republic of China. suyuh1227@hotmail.com.
Jinbao GaoDepartment of Hand and Foot Surgery, The Third Hospital of Shijiazhuang City, 15 South Tiyu Street, Shijiazhuang, 050000, People's Republic of China.
Chenbing ZhangDepartment of Hand and Foot Surgery, The Third Hospital of Shijiazhuang City, 15 South Tiyu Street, Shijiazhuang, 050000, People's Republic of China.
Hideaki TanakaDivision of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
First Hospital of Shijiazhuang · CNHebei Medical University · CNKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.

Indexed as

Cell MovementActin CytoskeletonAnimalsCell PolarityChick EmbryoChlorocebus aethiopsCOS CellsGene Expression Regulation, DevelopmentalIntercellular Signaling Peptides and ProteinsMice, KnockoutNeural CrestNeural TubeRecombinant Fusion ProteinsSpinal CordTorsodraxin protein, mouseIntercellular Signaling Peptides and ProteinsRecombinant Fusion ProteinsActin cytoskeletonAxon guidanceDraxinMigrationSpinal cordTrunk neural crest

Identifiers

PMID27649978
PMCPMC5258808
OpenAlexW2521975175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.