ReviewUltrasound in medicine & biology2016
Mechanisms for Induction of Pulmonary Capillary Hemorrhage by Diagnostic Ultrasound: Review and Consideration of Acoustical Radiation Surface Pressure.
Review in Ultrasound in medicine & biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Overview of Diagnostic Ultrasound Safety: Review for Research and Institutional Review Boards.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Review
- Surgery Without Scalpel: Histotripsy as a Non-Invasive and Non-Thermal Modality for Liver Tumor Ablation.Journal of clinical medicine · 2025Review
- Anaesthesia-induced atelectasis in a rat model (Frontiers in veterinary science · 2025Article
- Frame Rate Exposimetry for Pulmonary Capillary Hemorrhage During Lung Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023Article
- Lung Ultrasound Induction of Pulmonary Capillary Hemorrhage in Rats With Consideration of Exposimetric Relationships to Previous Similar Observations in Neonatal Swine.Ultrasound in medicine & biology · 2023Article
- New International Guidelines and Consensus on the Use of Lung Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023Review
- Perspective on ultrasound bioeffects and possible implications for continuous post-dive monitoring safety.Diving and hyperbaric medicine · 2022Review
- Safe and Effective Treatment of Compromised Clavicle Fracture of the Medial and Lateral Third Using Focused Shockwaves.Journal of clinical medicine · 2022Article
- The Influence of Xylazine and Clonidine on Lung Ultrasound-Induced Pulmonary Capillary Hemorrhage in Spontaneously Hypertensive Rats.Ultrasound in medicine & biology · 2021Article
- Hydrophone Spatial Averaging Correction for Acoustic Exposure Measurements From Arrays-Part I: Theory and Impact on Diagnostic Safety Indexes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Experimental Measurements of Ultrasound Attenuation in Human Chest Wall and Assessment of the Mechanical Index for Lung Ultrasound.Ultrasound in medicine & biology · 2020Article
- Low-frequency HIFU induced cancer immunotherapy: tempting challenges and potential opportunities.Cancer biology & medicine · 2019Article
- Pulmonary Capillary Hemorrhage Induced by Acoustic Radiation Force Impulse Shear Wave Elastography in Ventilated Rats.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Article
- Acoustic Fountains and Atomization at Liquid Surfaces Excited by Diagnostic Ultrasound.Ultrasound in medicine & biology · 2019Article
- GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.Xenotransplantation · 2018Article
- Does Intravenous Infusion Influence Diagnostic Ultrasound-Induced Pulmonary Capillary Hemorrhage?Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2018Article
- Pulmonary Capillary Hemorrhage Induced by Diagnostic Ultrasound in Ventilated Rats.Ultrasound in medicine & biology · 2018Article
- Pulmonary Capillary Hemorrhage Induced by Different Imaging Modes of Diagnostic Ultrasound.Ultrasound in medicine & biology · 2018Article
- The safety of pulmonary ultrasonography in the neonatal intensive care unit.Developmental period medicineArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Diagnostic ultrasound can induce pulmonary capillary hemorrhage (PCH) in rats and other mammals. This phenomenon represents the only clearly demonstrated biological effect of (non-contrast enhanced) diagnostic ultrasound and thus presents a uniquely important safety issue. However, the physical mechanism responsible for PCH remains uncertain more than 25 y after its discovery. Experimental research has indicated that neither heating nor acoustic cavitation, the predominant mechanisms for bioeffects of ultrasound, is responsible for PCH. Furthermore, proposed theoretical mechanisms based on gas-body activation, on alveolar resonance and on impulsive generation of liquid droplets all appear unlikely to be responsible for PCH, owing to unrealistic model assumptions. Here, a simple model based on the acoustical radiation surface pressure (ARSP) at a tissue-air interface is hypothesized as the mechanism for PCH. The ARSP model seems to explain some features of PCH, including the approximate frequency independence of PCH thresholds and the dependence of thresholds on biological factors. However, ARSP evaluated for experimental threshold conditions appear to be too weak to fully account for stress failure of pulmonary capillaries, gauging by known stresses for injurious physiologic conditions. Furthermore, consideration of bulk properties of lung tissue suggests substantial transmission of ultrasound through the pleura, with reduced ARSP and potential involvement of additional mechanisms within the pulmonary interior. Although these recent findings advance our knowledge, only a full understanding of PCH mechanisms will allow development of science-based safety assurance for pulmonary ultrasound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.