ArticleInternational journal of stroke : official journal of the International Stroke Society2017
Hyperlipidemia is associated with lower risk of poststroke mortality independent of statin use: A population-based study.
Article in International journal of stroke : official journal of the International Stroke Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Assessing the effectiveness of statin therapy for alleviating cerebral small vessel disease progression in people ≥75 years of age.BMC geriatrics · 2020Trial
- Predictors of in-hospital case-fatality in patients with stroke at the National Hospital of the Kyrgyz Republic: a retrospective cohort study.BMC neurology · 2026Article
- Trends and Disparities in Stroke Mortality Among Adults with Hyperlipidemia in the United States, 1999-2023.Journal of epidemiology and global health · 2025Article
- Association between blood triglycerides and stroke-associated pneumonia: a prospective cohort study.BMC neurology · 2025Article
- Epidemiological characteristics of asthma-COPD overlap, its association with all-cause mortality, and the mediating role of depressive symptoms: evidence from NHANES 2005-2018.BMC public health · 2024Article
- Development and internal validation of machine learning-based models and external validation of existing risk scores for outcome prediction in patients with ischaemic stroke.European heart journal. Digital health · 2024Article
- The Interplay of Dyslipidemia, Oxidative Stress, and Clinical Outcomes in Acute Ischemic Stroke Patients with and without Coronary Artery Disease.Biomedicines · 2024Article
- Sex Differences in Severity and Risk Factors for Ischemic Stroke in Patients With Hyperlipidemia.Neuroscience insights · 2024Article
- Associations Between Albuminuria and Mortality Among US Adults by Demographic and Comorbidity Factors.Journal of the American Heart Association · 2023Article
- Development and Validation of a Novel Score for Predicting Long-Term Mortality after an Acute Ischemic Stroke.International journal of environmental research and public health · 2023Article
- Initial in-hospital heart rate is associated with long-term survival in patients with acute ischemic stroke.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Mortality in patients with myocardial infarction and potential risk factors: A five-year data analysis.ARYA atherosclerosis · 2022Article
- Quantitative collateral score for the prediction of clinical outcomes in stroke patients: Better than visual grading.Frontiers in neuroscience · 2022Article
- Amiodarone is associated with increased short-term mortality in elderly atrial fibrillation patients with preserved ejection fraction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- Long-Term Use of Statins Lowering the Risk of Rehospitalization Caused by Ischemic Stroke Among Middle-Aged Hyperlipidemic Patients: A Population-Based Study.Frontiers in pharmacology · 2021Article
- Effect ofFrontiers in cardiovascular medicine · 2021Article
- Extended lipid profile in Romanian ischemic stroke patients in relation to stroke severity and outcome: a path analysis model.Archives of medical science : AMS · 2021Article
- Metabolic syndrome increases risk of venous thromboembolism recurrence after acute deep vein thrombosis.Blood advances · 2020Article
- Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke.BMC cardiovascular disorders · 2019Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
Background Although statin therapy is associated with reduced stroke and mortality risk, some studies report that higher lipid levels are associated with improved outcomes following ischemic stroke. Aims We examined the association of hyperlipidemia (HLD) combined with statin therapy on all-cause mortality in stroke patients. Methods All stroke patients in the Greater Cincinnati Northern Kentucky region of ∼1.3 million were identified using ICD-9 discharge codes in 2005 and 2010. Stroke patients with and without HLD were categorized based on their reported statin use at baseline or discharge into three groups: no-HLD/no-statins, HLD/no-statins, and HLD/on-statins. Cox proportional hazards model was used to estimate the risk of mortality at 30 days, 1 year, and 3 years poststroke. Results Overall, 77% (2953) of the 3813 ischemic stroke patients were diagnosed with HLD and 72% ( n = 2123) of those patients were on statin medications. The mean age was 70.0 ± 14.6 years, 56% were women, and 21% were black. In adjusted analyses, the HLD/no-statins group showed 35% (adjusted hazard ratio (aHR) = 0.65, 95% CI: 0.46-0.92), 27% (aHR = 0.73, 95% CI: 0.59-0.90), and 17% (aHR = 0.83, 95% CI: 0.70-0.97) reduced risk of mortality at 30 days, 1 year, and 3 years, respectively, poststroke, compared with no-HLD/no-statins group. The HLD/on-statins group showed an additional 17% significant survival benefit at 3 years poststroke compared with HLD/no-statins group. Conclusions A diagnosis of HLD in ischemic stroke patients is associated with reduced short- and long-term mortality, irrespective of statin use. Statin therapy is associated with significant, additional long-term survival benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.