Evidence map›Paper›PMID 27649681›Full record

ArticleJournal of ethnopharmacology2016

Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the "Mycoplasma mycoides cluster".

Francisca Kama-Kama, Jacob Midiwo, Joseph Nganga, Naomi Maina, Elise Schiek, Leonidah Kerubo Omosa, George Osanjo, Jan Naessens

Open access · hybridAbstract read
In one paragraph

Article in Journal of ethnopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Contagious Agalactia In Sheep And Goats: Current Perspectives.Veterinary medicine (Auckland, N.Z.) · 2019
    Review
  10. Antimycoplasmal Activities of Compounds fromFrontiers in pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Francisca Kama-KamaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya; Biosciences Eastern & Central Africa - International Livestock Research Institute, Old Naivasha Road, PO Box 30709, 00100 Nairobi, Kenya. Electronic address: franciscayeye@yahoo.fr.
Jacob MidiwoDepartment of Chemistry, School of Physical Sciences, University of Nairobi, P.O Box 30197, Nairobi, Kenya.
Joseph NgangaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya.
Naomi MainaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya.
Elise SchiekBiosciences Eastern & Central Africa - International Livestock Research Institute, Old Naivasha Road, PO Box 30709, 00100 Nairobi, Kenya.
Leonidah Kerubo OmosaDepartment of Chemistry, School of Physical Sciences, University of Nairobi, P.O Box 30197, Nairobi, Kenya.
George OsanjoDepartment of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P.O Box 30197, Nairobi, Kenya.
Jan NaessensBiosciences Eastern & Central Africa - International Livestock Research Institute, Old Naivasha Road, PO Box 30709, 00100 Nairobi, Kenya. Electronic address: jnaessens@ymail.com.
International Livestock Research Institute · KEUniversity of Nairobi · KEJomo Kenyatta University of Agriculture and Technology · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ethnopharmocological relevanceMembers of 'Mycoplasma mycoides cluster' are important ruminant pathogens in Africa. Diseases caused by these Mycoplasma negatively affect the agricultural sector especially in developing countries through losses in livestock productivity, mortality and international trade restrictions. There is therefore urgent need to develop antimicrobials from alternative sources such as medicinal plants to curb these diseases. In Kenya, smallholder farmers belonging to the Maasai, Kuria and Luo rely on traditional Kenyan herbals to treat respiratory symptoms in ruminants. In the current study extracts from some of these plants were tested against the growth of members of Mycoplasma mycoides cluster.

aimThis study aimed at identifying plants that exhibit antimycoplasmal activities using an ethnobotanical approach. MATERIALS AND

methodsKenyan farmers of Maasai, Luo and Kuria ethnic groups were interviewed for plant remedies given to livestock with respiratory syndromes. The plant materials were thereafter collected and crude extracts prepared using a mixture of 50% of methanol (MeOH) in dichloromethane (CH

resultsExtracts from five plants namely: Solanum aculeastrum, Albizia coriaria, Ekebergia capensis, Piliostigma thonningii and Euclea divinorum exhibited the highest activities against the Mycoplasma strains tested. Mycoplasma mycoides subsp. mycoides were more susceptible to these extracts than Mycoplasma mycoides subsp. capri and Mycoplasma capricolum susp. capricolum. The activities of the crude extracts varied with the solvent used for extraction. The MICs mean values of the active extracts varied from 0.02 to 0.6mg/ml.

conclusionsThe results suggested that these plants could potentially contain antimicrobial compounds that might be useful for the treatment of respiratory diseases in ruminants. Future work should focus on the isolation and identification of the active compounds from the plant extracts that showed interesting activities and evaluation of their antimicrobial and cytotoxic potential.

Indexed as

AnimalsAnti-Bacterial AgentsEthnobotanyEthnopharmacologyFarmersInterviews as TopicKenyaLivestockMicrobial Sensitivity TestsMycoplasma mycoidesPhytotherapyPlant ExtractsPlants, MedicinalPleuropneumonia, ContagiousSolventsVeterinary DrugsAnti-Bacterial AgentsPlant ExtractsSolventsVeterinary DrugsAntimicrobial activityEthnobotanyEthno-medicinal from plants from KenyaLivestockMycoplasma mycoides

Identifiers

PMID27649681
PMCPMC5081062
OpenAlexW2521043613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.