Evidence map›Paper›PMID 27649409›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment.

Xiaohong Bi, Ingo Grafe, Hao Ding, Rene Flores, Elda Munivez, Ming Ming Jiang, Brian Dawson, Brendan Lee, Catherine G Ambrose

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Insights into the bisphosphonate holiday: a preliminary FTIRI study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Trial
  2. Article
  3. Mechanical characterization ofCell biomaterials · 2026
    Article
  4. Review
  5. Review
  6. Anti-transforming growth factor-β treatment shows increased bone mass and strength in a novel mouse model for osteogenesis imperfecta type I.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  7. Article
  8. Review
  9. Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Preliminary study on the electromagnetic field treatment of osteoporosis in rats.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020
    Article
  19. New perspectives on the treatment of skeletal dysplasia.Therapeutic advances in endocrinology and metabolism · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaohong BiDepartment of Nanomedicine and Biomedical Engineering, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ingo GrafeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Hao DingDepartment of Nanomedicine and Biomedical Engineering, University of Texas Health Science Center at Houston, Houston, TX, USA.
Rene FloresAcademic and Research Affairs, University of Texas Health Science Center at Houston, Houston, TX, USA.
Elda MunivezDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ming Ming JiangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Brian DawsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Brendan LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Catherine G AmbroseDepartment of Orthopaedic Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI TOLIAS, KIMBERLY R · 1988 to 2013
$29.4M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Project 3: 3D ImagingU54AR068069 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee · 2014 to 2026
$19.3M
Project 3: Collagen post-translational modification and cross-linking in OIP01HD070394 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN · 2011 to 2020
$13.4M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Development of Spectroscopic Biomarkers of Bone Quality in Metastatic DiseaseK25CA149194 · NCI · VANDERBILT UNIVERSITY · PI BI, XIAOHONG · 2010 to 2013
$429k
NCI NIH HHS K25 CA149194NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIAMS NIH HHS U54 AR068069NICHD NIH HHS P01 HD070394NICHD NIH HHS P30 HD024064
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by brittle bones that are prone to fracture. Although previous studies in animal models investigated the mechanical properties and material composition of OI bone, little work has been conducted to statistically correlate these parameters to identify key compositional contributors to the impaired bone mechanical behaviors in OI. Further, although increased TGF-β signaling has been demonstrated as a contributing mechanism to the bone pathology in OI models, the relationship between mechanical properties and bone composition after anti-TGF-β treatment in OI has not been studied. Here, we performed follow-up analyses of femurs collected in an earlier study from OI mice with and without anti-TGF-β treatment from both recessive (Crtap

Indexed as

Genes, DominantGenes, RecessiveAnimalsBiomechanical PhenomenaBone and BonesCollagen Type IDisease Models, AnimalExtracellular Matrix ProteinsFemurMice, Inbred C57BLMolecular ChaperonesOsteogenesis ImperfectaProteinsRegression AnalysisSpectrum Analysis, RamanTransforming Growth Factor betaCol1a2 protein, mouseCollagen Type ICrtap protein, mouseExtracellular Matrix ProteinsMolecular ChaperonesProteinsTransforming Growth Factor betaANALYSIS/QUANTIFICATION OF BONEBIOMECHANICSMATRIX MINERALIZATIONOSTEOGENESIS IMPERFECTASTATISTICAL METHODS

Identifiers

PMID27649409
PMCPMC7894383
OpenAlexW2521802670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.