ArticleNature communications2016
A dendritic disinhibitory circuit mechanism for pathway-specific gating.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.Nature communications · 2026Article
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Voltage imaging as a window into neural computation.Neurophotonics · 2026Article
- Article
- Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.Communications biology · 2025Article
- Thalamocortical feedback selectively controls pyramidal neuron excitability.Nature communications · 2025Article
- State modulation in spatial networks with three interneuron subtypes.Science advances · 2025Article
- Cannabinoid overrides triggers of GABAergic plasticity in vestibular circuits and distorts the development of navigation.iScience · 2025Article
- Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Layer-specific control of inhibition by NDNF interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biophysical and computational insights from modeling human cortical pyramidal neurons.Frontiers in neuroscience · 2025Review
- Circuit-level modeling of prediction error computation of multi-dimensional features in voluntary actions.Frontiers in computational neuroscience · 2025Article
- Cognitive network interactions through communication subspaces in large-scale models of the neocortex.bioRxiv : the preprint server for biology · 2024Article
- Transcriptomic Correlates of State Modulation in GABAergic Interneurons: A Cross-Species Analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Flexible gating between subspaces in a neural network model of internally guided task switching.Nature communications · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
While reading a book in a noisy café, how does your brain 'gate in' visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find that if inputs from different pathways cluster on a pyramidal neuron dendrite, a pathway can be gated-on by a disinhibitory circuit motif. The branch-specific disinhibition can be achieved despite dense interneuronal connectivity, even with random connections. Moreover, clustering of input pathways on dendrites can naturally emerge through synaptic plasticity regulated by dendritic inhibition. This gating mechanism in a neural circuit is further demonstrated by performing a context-dependent decision-making task. The model suggests that cognitive flexibility engages top-down signalling of behavioural rule or context that targets specific classes of inhibitory neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.