ReviewInternational journal of molecular sciences2016
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Rosacea andMedicina (Kaunas, Lithuania) · 2026Pooled it
- Health-related Quality of Life of Patients with Rosacea: A Systematic Review and Meta-analysis of Real-world Data.Acta dermato-venereologica · 2024Pooled it
- Comparison of the efficacy of tea tree (Parasitology · 2020Pooled it
- 30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea.Journal of cosmetic dermatology · 2025Trial
- Effect on the Skin Microbiota of Oral Minocycline for Rosacea.Acta dermato-venereologica · 2023Trial
- A novel azelaic acid formulation for the topical treatment of inflammatory rosacea: A multicentre, prospective clinical trial.Journal of cosmetic dermatology · 2021Trial
- Photodynamic therapy for rosacea in Chinese patients.Photodiagnosis and photodynamic therapy · 2018Trial
- Gut-Skin Axis Revisited: A Nationwide Cohort Study on the Bi-directional Relationship Between Rosacea and Irritable Bowel Syndrome.Annals of dermatology · 2026Article
- Targeting Neurovascular Inflammation in Rosacea: A Systematic Review of Botulinum Toxin Therapy.Cureus · 2026Review
- Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea.Nature communications · 2026Article
- Tear Film Interferometry, Meibography, and Optical Coherence Tomography Angiography for Rosacea.Diseases (Basel, Switzerland) · 2026Article
- The exposomal imprint on rosacea: More than skin deep.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Poly-D,L-Lactic Acid in the Treatment of Rosacea.Aesthetic plastic surgery · 2026Article
- Depression and Anxiety in Patients with Rosacea and Their Impact on Quality of Life: A Cross-Sectional Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Unraveling the Mechanism of Cuochuangling Pills in Rosacea Treatment: An Integrated Approach Combining Network Pharmacology, Bioinformatics, and Experimental Validation.Clinical, cosmetic and investigational dermatology · 2026Article
- Could high serum neopterin levels serve as a biomarker for patients diagnosed with rosacea, specifically the papulopustular rosacea subtype?Open medicine (Warsaw, Poland) · 2026Article
- Neuro-immune-vascular interactions in rosacea and hypertension: a mechanistic review.Frontiers in immunology · 2026Review
- Blepharitis driven by microbiome dysbiosis andFrontiers in medicine · 2026Review
- The role of the skin microbiome in modulating rosacea.Postepy dermatologii i alergologii · 2026Review
- A Comprehensive Review of Azelaic Acid Pharmacological Properties, Clinical Applications, and Innovative Topical Formulations.Pharmaceuticals (Basel, Switzerland) · 2025Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.