Evidence map›Paper›PMID 27648687›Full record

ArticlePharmacogenomics2016

Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.

Roelof Aj Smit, Iris Postmus, Stella Trompet, Michael R Barnes, Helen Warren, Benoit J Arsenault, Daniel I Chasman, L Adrienne Cupples, Graham A Hitman, Ronald M Krauss and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Roelof Aj SmitDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Iris PostmusSection of Gerontology & Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Michael R BarnesWilliam Harvey Research Institute, Barts & The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Helen WarrenWilliam Harvey Research Institute, Barts & The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Benoit J ArsenaultCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
Daniel I ChasmanDivision of Preventive Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Graham A HitmanBlizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Ronald M KraussDepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Xiaohui LiInstitute for Translational Genomics & Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology & Health Services, University of Washington, Seattle, WA 98101, USA.
Charles M SteinDepartment of Medicine, Vanderbilt University, Nashville, TN 37232-6602, USA.
Jerome I RotterInstitute for Translational Genomics & Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
NIH Director's Pioneer Award (RMI)DP1OD000329 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCUNE, JOSEPH M · 2004 to 2008
$4.2M
Medical Research Council MR/K006584/1NCATS NIH HHS UL1 TR000124NIDDK NIH HHS P30 DK063491NIH HHS DP1 OD000329
6 · The paper itself

Abstract

aimsTo utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response.

methodsWe investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia.

resultsLead SNPs for APOE, SORT1 and NPC1L1 were associated with a decreased LDL-c response to statin treatment, as was overall genetic predisposition for increased LDL-c levels as quantified with 59 SNPs, with a 5.4% smaller statin response per standard deviation increase in genetically raised LDL-c levels.

conclusionGenetic predisposition for increased LDL-c level may decrease efficacy of statin therapy.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideCholesterol, LDLHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPharmacogeneticsTriglyceridesCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsTriglyceridesMR–Eggerpharmacogeneticsstatin therapy

Identifiers

PMID27648687
PMCPMC5558541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.