Evidence map›Paper›PMID 27648615›Full record

ArticleThe American journal of pathology2016

Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone.

Timothy N Trotter, Justin T Gibson, Tshering Lama Sherpa, Pramod S Gowda, Deniz Peker, Yang Yang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Timothy N TrotterDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Justin T GibsonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Tshering Lama SherpaDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Pramod S GowdaDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Deniz PekerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Yang YangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama; Comprehensive Cancer Center and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: yangyang@uabmc.edu.
University of Alabama at Birmingham · US

Funding

Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Heparanase regulation of osteolysis in multiple myeloma.R01CA151538 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YANG, YANG · 2011 to 2015
$1.4M
NCI NIH HHS R01 CA151538NIGMS NIH HHS T32 GM008111
6 · The paper itself

Abstract

Multiple myeloma (MM) cells reside in the bone marrow microenvironment and form complicated interactions with nonneoplastic, resident stromal cells. We previously found that aggressive MM cells shift osteoblast progenitors toward adipogenesis. In addition, adipocytes are among the most common cell types in the adult skeleton; both mature adipocytes and preadipocytes serve as endocrine cells that secrete a number of soluble molecules into the microenvironment. Therefore, we used a combination of in vivo and in vitro methods to test the hypothesis that an increase in adipocyte lineage cells feeds back to promote MM progression. The results of this study revealed that bone marrow from patients with MM indeed contains increased preadipocytes and significantly larger mature adipocytes than normal bone marrow. We also found that preadipocytes and mature adipocytes secrete many molecules important for supporting MM cells in the bone marrow and directly recruit MM cells through both monocyte chemotactic protein-1 and stromal cell-derived factor-1α. Co-culture experiments found that preadipocytes activate Wnt signaling and decrease cleaved caspase-3, whereas mature adipocytes activate ERK signaling in MM cells. Furthermore, mature adipocyte conditioned medium promotes MM growth, whereas co-culture with preadipocytes results in enhanced MM cell chemotaxis in vitro and increased tumor growth in bone in vivo. Combined, these data reveal the importance of preadipocytes and mature adipocytes on MM progression and represent a unique target in the bone marrow microenvironment.

Indexed as

AdipocytesAdipogenesisAnimalsBone and BonesBone MarrowBone Marrow CellsCaspase 3Cell LineChemokine CCL2Chemokine CXCL12Disease Models, AnimalHumansMaleMiceMice, Inbred C57BLMultiple MyelomaCaspase 3Ccl2 protein, mouseChemokine CCL2Chemokine CXCL12Cxcl12 protein, mouse

Identifiers

PMID27648615
PMCPMC5222958
OpenAlexW2518760925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.