Evidence map›Paper›PMID 27648483›Full record

ArticleACS nano2016

Enteric Micromotor Can Selectively Position and Spontaneously Propel in the Gastrointestinal Tract.

Jinxing Li, Soracha Thamphiwatana, Wenjuan Liu, Berta Esteban-Fernández de Ávila, Pavimol Angsantikul, Elodie Sandraz, Jianxing Wang, Tailin Xu, Fernando Soto, Valentin Ramez and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. A roadmap for next-generation nanomotors.Nature nanotechnology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Biorobotic Drug Delivery for Biomedical Applications.Molecules (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jinxing LiDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Soracha ThamphiwatanaDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Wenjuan LiuDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Berta Esteban-Fernández de ÁvilaDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Pavimol AngsantikulDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Elodie SandrazDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Jianxing WangDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Tailin XuDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Fernando SotoDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Valentin RamezDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Xiaolei WangDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Weiwei GaoDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Liangfang ZhangDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.
Joseph WangDepartment of Nanoengineering, University of California San Diego , La Jolla, California 92093, United States.

Funding

Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095168
6 · The paper itself

Abstract

The gastrointestinal (GI) tract, which hosts hundreds of bacteria species, becomes the most exciting organ for the emerging microbiome research. Some of these GI microbes are hostile and cause a variety of diseases. These bacteria colonize in different segments of the GI tract dependent on the local physicochemical and biological factors. Therefore, selectively locating therapeutic or imaging agents to specific GI segments is of significant importance for studying gut microbiome and treating various GI-related diseases. Herein, we demonstrate an enteric micromotor system capable of precise positioning and controllable retention in desired segments of the GI tract. These motors, consisting of magnesium-based tubular micromotors coated with an enteric polymer layer, act as a robust nanobiotechnology tool for site-specific GI delivery. The micromotors can deliver payload to a particular location via dissolution of their enteric coating to activate their propulsion at the target site toward localized tissue penetration and retention.

Indexed as

active deliverybiodistributiongastrointestinal tractmicromotorpH-responsive polymer

Identifiers

PMID27648483
PMCPMC5362361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.